N-acetylgalactosamine kinase

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In enzymology, a N-acetylgalactosamine kinase (EC 2.7.1.157) is an enzyme that catalyzes the chemical reaction

ATP + N-acetyl-D-galactosamine $\rightleftharpoons$ ADP + N-acetyl-alpha-D-galactosamine 1-phosphate

Thus, the two substrates of this enzyme are ATP and N-acetyl-D-galactosamine, whereas its two products are ADP and N-acetyl-alpha-D-galactosamine 1-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:N-acetyl-D-galactosamine 1-phosphotransferase. Other names in common use include GALK2, GK2, GalNAc kinase, and N-acetylgalactosamine (GalNAc)-1-phosphate kinase.

[edit] References

IUBMB entry for 2.7.1.157
BRENDA references for 2.7.1.157 (Recommended.)
PubMed references for 2.7.1.157
PubMed Central references for 2.7.1.157
Google Scholar references for 2.7.1.157
Pastuszak I, Drake R, Elbein AD (1996). "Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation". J. Biol. Chem. 271: 20776–82. PMID 8702831.
Pastuszak I, O'Donnell J, Elbein AD (1996). "Identification of the GalNAc kinase amino acid sequence". J. Biol. Chem. 271: 23653–6. PMID 8798585.
Thoden JB, Holden HM (2005). "The molecular architecture of human N-acetyl galactosamine kinase". J. Biol. Chem.. PMID 16006554.