N,N-dimethylformamidase

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In enzymology, a N,N-dimethylformamidase (EC 3.5.1.56) is an enzyme that catalyzes the chemical reaction

N,N-dimethylformamide + H₂O dimethylamine + formate

Thus, the two substrates of this enzyme are N,N-dimethylformamide and H₂O, whereas its two products are dimethylamine and formate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N,N-dimethylformamide amidohydrolase. Other names in common use include dimethylformamidase, and DMFase. This enzyme participates in glyoxylate and dicarboxylate metabolism. It employs one cofactor, iron.

[edit] References

• IUBMB entry for 3.5.1.56
• BRENDA references for 3.5.1.56 (Recommended.)
• PubMed references for 3.5.1.56
• PubMed Central references for 3.5.1.56
• Google Scholar references for 3.5.1.56
• Schar HP, Holzmann W, Ramos Tombo GM, Ghisalba O (1986). "Purification and characterization of N,N-dimethylformamidase from Pseudomonas DMF 3/3". Eur. J. Biochem. 158: 469–75. doi:10.1111/j.1432-1033.1986.tb09778.x. PMID 3732281. 

[edit] External links

The CAS registry number for this enzyme class is 104645-73-0.

• IUBMB entry for 3.5.1.56

• KEGG entry for 3.5.1.56

• BRENDA entry for 3.5.1.56

• NiceZyme view of 3.5.1.56

• EC2PDB: PDB structures for 3.5.1.56

• PRIAM entry for 3.5.1.56

• PUMA2 entry for 3.5.1.56

• IntEnz: Integrated Enzyme entry for 3.5.1.56

• MetaCyc entry for 3.5.1.56

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050116: N,N-dimethylformamidase

• AMIGO entry for GO code 0050116: N,N-dimethylformamidase