MYST2

From Wikipedia, the free encyclopedia

MYST histone acetyltransferase 2

Identifiers

MYST2; HBO1; HBOA

External IDs

OMIM: 609880 MGI: 2182799 HomoloGene: 5134

Gene ontology
Molecular Function:	• nucleic acid binding • transcription factor activity • H3/H4 histone acetyltransferase activity • protein binding • zinc ion binding • acyltransferase activity • transferase activity • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• DNA replication • transcription • regulation of transcription, DNA-dependent • chromatin modification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007067 (mRNA)
NP_008998 (protein)

NM_177619 (mRNA)
NP_808287 (protein)

Location

Chr 17: 45.22 - 45.26 Mb

Chr 11: 95.09 - 95.13 Mb

Pubmed search

[1]

[2]

MYST histone acetyltransferase 2, also known as MYST2, is a human gene.^[1]

[edit] References

^ Entrez Gene: MYST2 MYST histone acetyltransferase 2.

[edit] Further reading

Iizuka M, Stillman B (1999). "Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein.". J. Biol. Chem. 274 (33): 23027-34. PMID 10438470.
Sharma M, Zarnegar M, Li X, et al. (2001). "Androgen receptor interacts with a novel MYST protein, HBO1.". J. Biol. Chem. 275 (45): 35200-8. doi:10.1074/jbc.M004838200. PMID 10930412.
Burke TW, Cook JG, Asano M, Nevins JR (2001). "Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1.". J. Biol. Chem. 276 (18): 15397-408. doi:10.1074/jbc.M011556200. PMID 11278932.
Yanagisawa J, Kitagawa H, Yanagida M, et al. (2002). "Nuclear receptor function requires a TFTC-type histone acetyl transferase complex.". Mol. Cell 9 (3): 553-62. PMID 11931763.
Cervoni N, Detich N, Seo SB, et al. (2002). "The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing.". J. Biol. Chem. 277 (28): 25026-31. doi:10.1074/jbc.M202256200. PMID 11978794.
Sharma D, Fondell JD (2002). "Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo.". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 7934-9. doi:10.1073/pnas.122004799. PMID 12034878.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell 15 (6): 853-65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Zong H, Li Z, Liu L, et al. (2005). "Cyclin-dependent kinase 11(p58) interacts with HBO1 and enhances its histone acetyltransferase activity.". FEBS Lett. 579 (17): 3579-88. doi:10.1016/j.febslet.2005.05.039. PMID 15963510.
Cereseto A, Manganaro L, Gutierrez MI, et al. (2005). "Acetylation of HIV-1 integrase by p300 regulates viral integration.". EMBO J. 24 (17): 3070-81. doi:10.1038/sj.emboj.7600770. PMID 16096645.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Doyon Y, Cayrou C, Ullah M, et al. (2006). "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.". Mol. Cell 21 (1): 51-64. doi:10.1016/j.molcel.2005.12.007. PMID 16387653.
Iizuka M, Matsui T, Takisawa H, Smith MM (2006). "Regulation of replication licensing by acetyltransferase Hbo1.". Mol. Cell. Biol. 26 (3): 1098-108. doi:10.1128/MCB.26.3.1098-1108.2006. PMID 16428461.
Georgiakaki M, Chabbert-Buffet N, Dasen B, et al. (2006). "Ligand-controlled interaction of histone acetyltransferase binding to ORC-1 (HBO1) with the N-terminal transactivating domain of progesterone receptor induces steroid receptor coactivator 1-dependent coactivation of transcription.". Mol. Endocrinol. 20 (9): 2122-40. doi:10.1210/me.2005-0149. PMID 16645042.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Topper M, Luo Y, Zhadina M, et al. (2007). "Posttranslational acetylation of the human immunodeficiency virus type 1 integrase carboxyl-terminal domain is dispensable for viral replication.". J. Virol. 81 (6): 3012-7. doi:10.1128/JVI.02257-06. PMID 17182677.