Myristoyl-CoA 11-(Z) desaturase

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In enzymology, a myristoyl-CoA 11-(Z) desaturase (EC 1.14.99.32) is an enzyme that catalyzes the chemical reaction

myristoyl-CoA + NAD(P)H + H⁺ + O₂ (Z)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H₂O

The 5 substrates of this enzyme are myristoyl-CoA, NADH, NADPH, H⁺, and O₂, whereas its 4 products are (Z)-11-tetradecenoyl-CoA, NAD⁺, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(Z) desaturating]. This enzyme is also called n-tetradecanoyl-CoA,NADPH:O2 oxidoreductase [11-(Z) desaturating].

[edit] References

• IUBMB entry for 1.14.99.32
• BRENDA references for 1.14.99.32 (Recommended.)
• PubMed references for 1.14.99.32
• PubMed Central references for 1.14.99.32
• Google Scholar references for 1.14.99.32
• Navaro I, Font I, Fabrias G and Camps F (1997). "Stereospecificity of the (E)- and (Z)-11 myristoyl desaturases in the biosynthesis of Spodoptera littoralis sex pheromone". J. Am. Chem. Soc. 119: 11335–11336. doi:10.1021/ja972577v. 

[edit] External links

• IUBMB entry for 1.14.99.32

• KEGG entry for 1.14.99.32

• BRENDA entry for 1.14.99.32

• NiceZyme view of 1.14.99.32

• EC2PDB: PDB structures for 1.14.99.32

• PRIAM entry for 1.14.99.32

• PUMA2 entry for 1.14.99.32

• IntEnz: Integrated Enzyme entry for 1.14.99.32

• MetaCyc entry for 1.14.99.32

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050601: myristoyl-CoA 11-(Z) desaturase

• AMIGO entry for GO code 0050601: myristoyl-CoA 11-(Z) desaturase