Myriocin

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Myriocin
Myriocin
Identifiers
CAS number [35891-70-4]
Properties
Molecular formula C21H39NO6
Molar mass 401.54 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Myriocin, also known as Antibiotic ISP-1, Thermozymocidin, is an atypic amino acid, an antibiotic derived from certain thermophilic fungi. Among the producing strains are Mycelia sterilia[1]and Isaria sinclairii.

Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis[2]. Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids.

Myriocin was shown to inhibit the proliferation of an IL-2-dependent mouse cytotoxic T cell line.

Myriocin possesses immunosuppressant activity. It is reported to be 10 to 100 fold more potent than cyclosporin.

[edit] See also

[edit] References

  1. ^ Source: Myriocin from Fermentek
  2. ^ Miyake Y, Kozutsumi Y, Nakamura S, Fujita T, Kawasaki T (1995). "Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin". Biochem. Biophys. Res. Commun. 211 (2): 396–403. doi:10.1006/bbrc.1995.1827. PMID 7794249. 
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