MYPN

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Myopalladin
Identifiers
Symbol(s) MYPN; MYOP
External IDs OMIM: 608517 MGI: 1916052 HomoloGene: 23778
Orthologs
Human Mouse
Entrez 84665 68802
Ensembl ENSG00000138347 ENSMUSG00000020067
Uniprot Q86TC9 Q5DTJ9
Refseq NM_032578 (mRNA)
NP_115967 (protein)		 XM_483911 (mRNA)
XP_483911 (protein)
Location Chr 10: 69.54 - 69.64 Mb Chr 10: 62.51 - 62.6 Mb
Pubmed search [1] [2]

Myopalladin, also known as MYPN, is a human gene.[1]

MYPN is a component of the sarcomere that tethers nebulin (MIM 161650) in skeletal muscle and nebulette (MIM 605491) in cardiac muscle to alpha-actinin (see ACTN2; MIM 102573) at the Z lines (Bang et al., 2001).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: MYPN myopalladin.

[edit] Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166. 
  • Bang ML, Mudry RE, McElhinny AS, et al. (2001). "Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies.". J. Cell Biol. 153 (2): 413–27. PMID 11309420. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ma K, Wang K (2003). "Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin.". FEBS Lett. 532 (3): 273–8. PMID 12482578. 
  • Miller MK, Bang ML, Witt CC, et al. (2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules.". J. Mol. Biol. 333 (5): 951–64. PMID 14583192. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901. 
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
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