Myo-inosose-2 dehydratase

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In enzymology, a myo-inosose-2 dehydratase (EC 4.2.1.44) is an enzyme that catalyzes the chemical reaction

2,4,6/3,5-pentahydroxycyclohexanone 3,5/4-trihydroxycyclohexa-1,2-dione + H₂O

Hence, this enzyme has one substrate, 2,4,6/3,5-pentahydroxycyclohexanone, and two products, 3,5/4-trihydroxycyclohexa-1,2-dione and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase (3,5/4-trihydroxycyclohexa-1,2-dione-forming). Other names in common use include inosose 2,3-dehydratase, ketoinositol dehydratase, and 2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase. This enzyme participates in inositol phosphate metabolism. It has 2 cofactors: manganese, and Cobalt.

[edit] References

• IUBMB entry for 4.2.1.44
• BRENDA references for 4.2.1.44 (Recommended.)
• PubMed references for 4.2.1.44
• PubMed Central references for 4.2.1.44
• Google Scholar references for 4.2.1.44
• Berman T, Magasanik B (1966). "The pathway of myo-inositol degradation in Aerobacter aerogenes Dehydrogenation and dehydration". J. Biol. Chem. 241: 800–6. PMID 5905122. 

[edit] External links

The CAS registry number for this enzyme class is 37290-79-2.

• IUBMB entry for 4.2.1.44

• KEGG entry for 4.2.1.44

• BRENDA entry for 4.2.1.44

• NiceZyme view of 4.2.1.44

• EC2PDB: PDB structures for 4.2.1.44

• PRIAM entry for 4.2.1.44

• PUMA2 entry for 4.2.1.44

• IntEnz: Integrated Enzyme entry for 4.2.1.44

• MetaCyc entry for 4.2.1.44

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050114: myo-inosose-2 dehydratase

• AMIGO entry for GO code 0050114: myo-inosose-2 dehydratase