MYOM2

From Wikipedia, the free encyclopedia

Myomesin (M-protein) 2, 165kDa

Identifiers

External IDs

OMIM: 603509 MGI: 1328358 HomoloGene: 2953

Gene ontology
Molecular Function:	• structural constituent of muscle
Cellular Component:	• striated muscle thick filament
Biological Process:	• striated muscle contraction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_003970 (mRNA)
NP_003961 (protein)

NM_008664 (mRNA)
NP_032690 (protein)

Location

Chr 8: 1.98 - 2.08 Mb

Chr 8: 15.06 - 15.13 Mb

Pubmed search

[1]

[2]

Myomesin (M-protein) 2, 165kDa, also known as MYOM2, is a human gene.^[1]

The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD and 165 kD. The predicted MYOM2 protein contains 1,465 amino acids. Like MYOM1, MYOM2 has a unique N-terminal domain followed by 12 repeat domains with strong homology to either fibronectin type III or immunoglobulin C2 domains. Protein sequence comparisons suggested that the MYOM2 protein and bovine M protein are identical.^[1]

[edit] References

^ ^a ^b Entrez Gene: MYOM2 myomesin (M-protein) 2, 165kDa.

[edit] Further reading

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711-8. doi:10.1101/gr.2435604. PMID 15342556.
Hornemann T, Kempa S, Himmel M, et al. (2003). "Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein.". J. Mol. Biol. 332 (4): 877-87. PMID 12972258.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
van der Ven PF, Speel EJ, Albrechts JC, et al. (1999). "Assignment of the human gene for endosarcomeric cytoskeletal M-protein (MYOM2) to 8p23.3.". Genomics 55 (2): 253-5. doi:10.1006/geno.1998.5603. PMID 9933576.
Obermann WM, van der Ven PF, Steiner F, et al. (1998). "Mapping of a myosin-binding domain and a regulatory phosphorylation site in M-protein, a structural protein of the sarcomeric M band.". Mol. Biol. Cell 9 (4): 829-40. PMID 9529381.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Vinkemeier U, Obermann W, Weber K, Fürst DO (1994). "The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins.". J. Cell. Sci. 106 ( Pt 1): 319-30. PMID 7505783.