MYOM1

From Wikipedia, the free encyclopedia

Myomesin 1 (skelemin) 185kDa

Identifiers

MYOM1; MGC134946; MGC134947; SKELEMIN

External IDs

OMIM: 603508 MGI: 1341430 HomoloGene: 31196

Gene ontology
Molecular Function:	• structural constituent of muscle
Cellular Component:	• striated muscle thick filament • myofibril
Biological Process:	• striated muscle contraction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003803 (mRNA)
NP_003794 (protein)

NM_010867 (mRNA)
NP_034997 (protein)

Location

Chr 18: 3.06 - 3.21 Mb

Chr 17: 70.92 - 71.03 Mb

Pubmed search

[1]

[2]

Myomesin 1 (skelemin) 185kDa, also known as MYOM1, is a human gene.^[1]

The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: MYOM1 myomesin 1 (skelemin) 185kDa.

[edit] Further reading

Grove BK, Kurer V, Lehner C, et al. (1984). "A new 185,000-dalton skeletal muscle protein detected by monoclonal antibodies.". J. Cell Biol. 98 (2): 518–24. PMID 6537951.
Vinkemeier U, Obermann W, Weber K, Fürst DO (1994). "The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins.". J. Cell. Sci. 106 ( Pt 1): 319–30. PMID 7505783.
Obermann WM, Plessmann U, Weber K, Fürst DO (1995). "Purification and biochemical characterization of myomesin, a myosin-binding and titin-binding protein, from bovine skeletal muscle.". Eur. J. Biochem. 233 (1): 110–5. PMID 7588733.
Speel EJ, van der Ven PF, Albrechts JC, et al. (1999). "Assignment of the human gene for the sarcomeric M-band protein myomesin (MYOM1) to 18p11.31-p11.32.". Genomics 54 (1): 184–6. doi:10.1006/geno.1998.5503. PMID 9806852.
Steiner F, Weber K, Fürst DO (1999). "M band proteins myomesin and skelemin are encoded by the same gene: analysis of its organization and expression.". Genomics 56 (1): 78–89. doi:10.1006/geno.1998.5682. PMID 10036188.
Agarkova I, Auerbach D, Ehler E, Perriard JC (2000). "A novel marker for vertebrate embryonic heart, the EH-myomesin isoform.". J. Biol. Chem. 275 (14): 10256–64. PMID 10744711.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Porter JD, Merriam AP, Gong B, et al. (2004). "Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscle.". J. Exp. Biol. 206 (Pt 17): 3101–12. PMID 12878677.
Hornemann T, Kempa S, Himmel M, et al. (2003). "Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein.". J. Mol. Biol. 332 (4): 877–87. PMID 12972258.
Lange S, Himmel M, Auerbach D, et al. (2005). "Dimerisation of myomesin: implications for the structure of the sarcomeric M-band.". J. Mol. Biol. 345 (2): 289–98. doi:10.1016/j.jmb.2004.10.040. PMID 15571722.
Schoenauer R, Bertoncini P, Machaidze G, et al. (2005). "Myomesin is a molecular spring with adaptable elasticity.". J. Mol. Biol. 349 (2): 367–79. doi:10.1016/j.jmb.2005.03.055. PMID 15890201.