MYOC

From Wikipedia, the free encyclopedia

Myocilin, trabecular meshwork inducible glucocorticoid response

Identifiers

MYOC; GLC1A; GPOA; JOAG; JOAG1; TIGR; myocilin

External IDs

OMIM: 601652 MGI: 1202864 HomoloGene: 220

Gene ontology
Molecular Function:	• structural molecule activity • protein binding • latrotoxin receptor activity
Cellular Component:	• endoplasmic reticulum • cilium • membrane
Biological Process:	• visual perception • anatomical structure morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000261 (mRNA)
NP_000252 (protein)

NM_010865 (mRNA)
NP_034995 (protein)

Location

Chr 1: 169.87 - 169.89 Mb

Chr 1: 164.48 - 164.49 Mb

Pubmed search

[1]

[2]

Myocilin, trabecular meshwork inducible glucocorticoid response, also known as MYOC, is a human gene.

MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.^[1]

[edit] References

^ Entrez Gene: MYOC myocilin, trabecular meshwork inducible glucocorticoid response.

[edit] Further reading

Fingert JH, Stone EM, Sheffield VC, Alward WL (2003). "Myocilin glaucoma.". Survey of ophthalmology 47 (6): 547-61. PMID 12504739.
Polansky JR (2004). "Current perspectives on the TIGR/MYOC gene (Myocilin) and glaucoma.". Ophthalmology clinics of North America 16 (4): 515-27, v-vi. PMID 14740993.
Coca-Prados M, Escribano J (2007). "New perspectives in aqueous humor secretion and in glaucoma: the ciliary body as a multifunctional neuroendocrine gland.". Progress in retinal and eye research 26 (3): 239-62. doi:10.1016/j.preteyeres.2007.01.002. PMID 17321191.