MYO6

From Wikipedia, the free encyclopedia

Myosin VI

PDB rendering based on 2bkh.

Available structures: 2bkh, 2bki

Identifiers

Symbol(s)

MYO6; DFNA22; DFNB37; KIAA0389

External IDs

OMIM: 600970 MGI: 104785 HomoloGene: 56417

Gene ontology
Molecular Function:	• nucleotide binding • motor activity • calmodulin binding • ATP binding • protein homodimerization activity • ADP binding • actin filament binding • minus-end directed microfilament motor activity
Cellular Component:	• ruffle • nucleus • nucleoplasm • cytoplasm • Golgi apparatus • coated pit • cell cortex • membrane • unconventional myosin complex • DNA-directed RNA polymerase II, holoenzyme • filamentous actin • nuclear membrane • clathrin-coated endocytic vesicle • perinuclear region of cytoplasm
Biological Process:	• intracellular protein transport • endocytosis • synaptogenesis • sensory perception of sound • dendrite development • actin filament-based movement • DNA damage response, signal transduction by p53 class mediator • positive regulation of transcription from RNA polymerase II promoter • regulation of secretion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004999 (mRNA)
NP_004990 (protein)

NM_001039546 (mRNA)
NP_001034635 (protein)

Location

Chr 6: 76.52 - 76.68 Mb

Chr 9: 79.95 - 80.1 Mb

Pubmed search

[1]

[2]

Myosin VI, also known as MYO6, is a human gene.

Myosin VI is a molecular motor involved in intracellular vesicle and organelle transport. It is one of the so-called unconventional myosins.[supplied by OMIM]^[1]

[edit] References

^ Entrez Gene: MYO6 myosin VI.

[edit] Further reading

Buss F, Luzio JP, Kendrick-Jones J (2001). "Myosin VI, a new force in clathrin mediated endocytosis.". FEBS Lett. 508 (3): 295–9. PMID 11728438.
Hasson T (2004). "Myosin VI: two distinct roles in endocytosis.". J. Cell. Sci. 116 (Pt 17): 3453–61. doi:10.1242/jcs.00669. PMID 12893809.
Avraham KB, Hasson T, Steel KP, et al. (1996). "The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells.". Nat. Genet. 11 (4): 369–75. doi:10.1038/ng1295-369. PMID 7493015.
Bement WM, Hasson T, Wirth JA, et al. (1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6549–53. PMID 8022818.
Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. PMID 9205841.
Avraham KB, Hasson T, Sobe T, et al. (1997). "Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice.". Hum. Mol. Genet. 6 (8): 1225–31. PMID 9259267.
Buss F, Kendrick-Jones J, Lionne C, et al. (1999). "The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation.". J. Cell Biol. 143 (6): 1535–45. PMID 9852149.
Wells AL, Lin AW, Chen LQ, et al. (1999). "Myosin VI is an actin-based motor that moves backwards.". Nature 401 (6752): 505–8. doi:10.1038/46835. PMID 10519557.
Buss F, Arden SD, Lindsay M, et al. (2001). "Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis.". EMBO J. 20 (14): 3676–84. doi:10.1093/emboj/20.14.3676. PMID 11447109.
Melchionda S, Ahituv N, Bisceglia L, et al. (2001). "MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss.". Am. J. Hum. Genet. 69 (3): 635–40. PMID 11468689.
Yoshimura M, Homma K, Saito J, et al. (2001). "Dual regulation of mammalian myosin VI motor function.". J. Biol. Chem. 276 (43): 39600–7. doi:10.1074/jbc.M105080200. PMID 11517222.
Rock RS, Rice SE, Wells AL, et al. (2002). "Myosin VI is a processive motor with a large step size.". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13655–9. doi:10.1073/pnas.191512398. PMID 11707568.
Inoue A, Sato O, Homma K, Ikebe M (2002). "DOC-2/DAB2 is the binding partner of myosin VI.". Biochem. Biophys. Res. Commun. 292 (2): 300–7. doi:10.1006/bbrc.2002.6636. PMID 11906161.
Morris SM, Arden SD, Roberts RC, et al. (2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton.". Traffic 3 (5): 331–41. PMID 11967127.
Wu H, Nash JE, Zamorano P, Garner CC (2002). "Interaction of SAP97 with minus-end-directed actin motor myosin VI. Implications for AMPA receptor trafficking.". J. Biol. Chem. 277 (34): 30928–34. doi:10.1074/jbc.M203735200. PMID 12050163.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ahmed ZM, Morell RJ, Riazuddin S, et al. (2003). "Mutations of MYO6 are associated with recessive deafness, DFNB37.". Am. J. Hum. Genet. 72 (5): 1315–22. PMID 12687499.
Aschenbrenner L, Lee T, Hasson T (2004). "Myo6 facilitates the translocation of endocytic vesicles from cell peripheries.". Mol. Biol. Cell 14 (7): 2728–43. doi:10.1091/mbc.E02-11-0767. PMID 12857860.