MYO5A

From Wikipedia, the free encyclopedia

Myosin VA (heavy chain 12, myoxin)

PDB rendering based on 1oe9.

Available structures: 1oe9, 1w7i, 1w7j, 1w8j, 2ix7

Identifiers

Symbol(s)

MYO5A; GS1; MYH12; MYO5; MYOXIN; MYR12; myosin V; myosin Va

External IDs

OMIM: 160777 MGI: 105976 HomoloGene: 20100

Gene ontology
Molecular Function:	• microfilament motor activity • nucleotide binding • molecular_function • motor activity • actin binding • iron ion binding • calmodulin binding • ATP binding • electron carrier activity • heme binding
Cellular Component:	• ruffle • cytoplasm • myosin complex • growth cone • neuron projection
Biological Process:	• electron transport • transport • biological_process • actin filament-based movement

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000259 (mRNA)
NP_000250 (protein)

NM_010864 (mRNA)
NP_034994 (protein)

Location

Chr 15: 50.39 - 50.61 Mb

Chr 9: 74.9 - 75 Mb

Pubmed search

[1]

[2]

Myosin VA (heavy chain 12, myoxin), also known as MYO5A, is a human gene.^[1]

[edit] See also

[edit] References

^ Entrez Gene: MYO5A myosin VA (heavy chain 12, myoxin).

[edit] Further reading

Moore KJ, Testa JR, Francke U, et al. (1995). "Cloning and regional assignment of the human myosin heavy chain 12 (MYH12) gene to chromosome band 15q21.". Cytogenet. Cell Genet. 69 (1-2): 53–8. PMID 7835087.
Bement WM, Hasson T, Wirth JA, et al. (1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6549–53. PMID 8022818.
Engle LJ, Kennett RH (1994). "Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene.". Genomics 19 (3): 407–16. doi:10.1006/geno.1994.1088. PMID 8188282.
Pastural E, Barrat FJ, Dufourcq-Lagelouse R, et al. (1997). "Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene.". Nat. Genet. 16 (3): 289–92. doi:10.1038/ng0797-289. PMID 9207796.
Lambert J, Naeyaert JM, Callens T, et al. (1998). "Human myosin V gene produces different transcripts in a cell type-specific manner.". Biochem. Biophys. Res. Commun. 252 (2): 329–33. doi:10.1006/bbrc.1998.9644. PMID 9826529.
Buss F, Kendrick-Jones J, Lionne C, et al. (1999). "The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation.". J. Cell Biol. 143 (6): 1535–45. PMID 9852149.
El-Husseini AE, Vincent SR (1999). "Cloning and characterization of a novel RING finger protein that interacts with class V myosins.". J. Biol. Chem. 274 (28): 19771–7. PMID 10391919.
Mehta AD, Rock RS, Rief M, et al. (1999). "Myosin-V is a processive actin-based motor.". Nature 400 (6744): 590–3. doi:10.1038/23072. PMID 10448864.
Edgar AJ, Bennett JP (1999). "Inhibition of dendrite formation in mouse melanocytes transiently transfected with antisense DNA to myosin Va.". J. Anat. 195 ( Pt 2): 173–84. PMID 10529054.
Pastural E, Ersoy F, Yalman N, et al. (2000). "Two genes are responsible for Griscelli syndrome at the same 15q21 locus.". Genomics 63 (3): 299–306. doi:10.1006/geno.1999.6081. PMID 10704277.
Lambert J, Naeyaert JM, De Paepe A, et al. (2000). "arg-cys substitution at codon 1246 of the human myosin Va gene is not associated with Griscelli syndrome.". J. Invest. Dermatol. 114 (4): 731–3. doi:10.1046/j.1523-1747.2000.00933.x. PMID 10733681.
Naisbitt S, Valtschanoff J, Allison DW, et al. (2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein.". J. Neurosci. 20 (12): 4524–34. PMID 10844022.
Lo KW, Naisbitt S, Fan JS, et al. (2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif.". J. Biol. Chem. 276 (17): 14059–66. doi:10.1074/jbc.M010320200. PMID 11148209.
Ohkawa N, Kokura K, Matsu-Ura T, et al. (2001). "Molecular cloning and characterization of neural activity-related RING finger protein (NARF): a new member of the RBCC family is a candidate for the partner of myosin V.". J. Neurochem. 78 (1): 75–87. PMID 11432975.
Fukuda M, Kuroda TS, Mikoshiba K (2002). "Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport.". J. Biol. Chem. 277 (14): 12432–6. doi:10.1074/jbc.C200005200. PMID 11856727.
Rodriguez OC, Cheney RE (2002). "Human myosin-Vc is a novel class V myosin expressed in epithelial cells.". J. Cell. Sci. 115 (Pt 5): 991–1004. PMID 11870218.
Strom M, Hume AN, Tarafder AK, et al. (2002). "A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport.". J. Biol. Chem. 277 (28): 25423–30. doi:10.1074/jbc.M202574200. PMID 11980908.
Wu X, Wang F, Rao K, et al. (2002). "Rab27a is an essential component of melanosome receptor for myosin Va.". Mol. Biol. Cell 13 (5): 1735–49. doi:10.1091/mbc.01-12-0595. PMID 12006666.
Anikster Y, Huizing M, Anderson PD, et al. (2002). "Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A.". Am. J. Hum. Genet. 71 (2): 407–14. PMID 12058346.
Nagashima K, Torii S, Yi Z, et al. (2002). "Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions.". FEBS Lett. 517 (1-3): 233–8. PMID 12062444.