MYO18B

From Wikipedia, the free encyclopedia

Myosin XVIIIB

Identifiers

MYO18B; DKFZp434C2422; DKFZp779C1668; FLJ41942

External IDs

OMIM: 607295 MGI: 1921626 HomoloGene: 53435

Gene ontology
Molecular Function:	• nucleotide binding • motor activity • actin binding • ATP binding
Cellular Component:	• nucleus • unconventional myosin complex

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_032608 (mRNA)
NP_115997 (protein)

XM_912851 (mRNA)
XP_917944 (protein)

Location

Chr 22: 24.49 - 24.76 Mb

Chr 5: 113.06 - 113.11 Mb

Pubmed search

[1]

[2]

Myosin XVIIIB, also known as MYO18B, is a human gene.^[1]

The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer.^[1]

[edit] References

^ ^a ^b Entrez Gene: MYO18B myosin XVIIIB.

[edit] Further reading

Yokota J, Nishioka M, Tani M, Kohno T (2003). "Genetic alterations responsible for metastatic phenotypes of lung cancer cells.". Clin. Exp. Metastasis 20 (3): 189-93. PMID 12741677.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208.
Nishioka M, Kohno T, Tani M, et al. (2002). "MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer.". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12269-74. doi:10.1073/pnas.192445899. PMID 12209013.
Salamon M, Millino C, Raffaello A, et al. (2003). "Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation.". J. Mol. Biol. 326 (1): 137-49. PMID 12547197.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Yanaihara N, Nishioka M, Kohno T, et al. (2004). "Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer.". Int. J. Cancer 112 (1): 150-4. doi:10.1002/ijc.20339. PMID 15305387.
Inoue T, Kon T, Ajima R, et al. (2006). "MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway.". Biochem. Biophys. Res. Commun. 342 (3): 829-34. doi:10.1016/j.bbrc.2006.02.025. PMID 16499872.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Edakuni N, Ikuta K, Yano S, et al. (2007). "Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice.". Oncol. Res. 16 (5): 235-43. PMID 17294804.