MYL6

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Myosin, light chain 6, alkali, smooth muscle and non-muscle
PDB rendering based on 1br1.
Available structures: 1br1, 1br4, 1i84
Identifiers
Symbol(s) MYL6; ESMLC; LC17-GI; LC17-NM; LC17A; LC17B; MLC1SM; MLC3NM; MLC3SM
External IDs OMIM: 609931 MGI: 109318 HomoloGene: 69080
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4637 17904
Ensembl ENSG00000092841 n/a
Uniprot P60660 n/a
Refseq NM_021019 (mRNA)
NP_066299 (protein)		 NM_010860 (mRNA)
NP_034990 (protein)
Location Chr 12: 54.84 - 54.84 Mb n/a
Pubmed search [1] [2]

Myosin, light chain 6, alkali, smooth muscle and non-muscle, also known as MYL6, is a human gene.[1]

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle.

[edit] Further reading

  • Hailstones DL, Gunning PW (1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function.". Mol. Cell. Biol. 10 (3): 1095–104. PMID 2304459. 
  • Lenz S, Lohse P, Seidel U, Arnold HH (1989). "The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways.". J. Biol. Chem. 264 (15): 9009–15. PMID 2722814. 
  • Bora PS, Bora NS, Wu X, et al. (1994). "Molecular cloning, sequencing, and characterization of smooth muscle myosin alkali light chain from human eye cDNA: homology with myocardial fatty acid ethyl ester synthase-III cDNA.". Genomics 19 (1): 186–8. doi:10.1006/geno.1994.1041. PMID 8188229. 
  • Komiyama M, Soldati T, von Arx P, Perriard JC (1997). "The intracompartmental sorting of myosin alkali light chain isoproteins reflects the sequence of developmental expression as determined by double epitope-tagging competition.". J. Cell. Sci. 109 ( Pt 8): 2089–99. PMID 8856505. 
  • Watanabe M, Kohri M, Takaishi M, et al. (2001). "Molecular cloning and sequencing of myosin light chains in human megakaryoblastic leukemia cells.". Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 37 (1): 25–38. PMID 11436981. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. 
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Fu ZY, Xie BT, Ma YT, Gong ZX (2006). "Preparation of monoclonal antibodies against human ventricular myosin light chain 1 (HVMLC1) for functional studies.". Acta Biochim. Biophys. Sin. (Shanghai) 38 (9): 625–32. PMID 16953301. 
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