MYL4

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Myosin, light chain 4, alkali; atrial, embryonic
Identifiers
Symbol(s) MYL4; GT1; ALC1; AMLC; PRO1957
External IDs OMIM: 160770 MGI: 97267 HomoloGene: 20558
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4635 17896
Ensembl ENSG00000198336 ENSMUSG00000061086
Uniprot P12829 Q9CZ19
Refseq NM_001002841 (mRNA)
NP_001002841 (protein)		 NM_010858 (mRNA)
NP_034988 (protein)
Location Chr 17: 42.64 - 42.66 Mb Chr 11: 104.37 - 104.4 Mb
Pubmed search [1] [2]

Myosin, light chain 4, alkali; atrial, embryonic, also known as MYL4, is a human gene.[1]

Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: MYL4 myosin, light chain 4, alkali; atrial, embryonic.

[edit] Further reading

  • Rotter M, Zimmerman K, Poustka A, et al. (1991). "The human embryonic myosin alkali light chain gene: use of alternative promoters and 3' non-coding regions.". Nucleic Acids Res. 19 (7): 1497-504. PMID 2027757. 
  • Seharaseyon J, Bober E, Hsieh CL, et al. (1990). "Human embryonic/atrial myosin alkali light chain gene: characterization, sequence, and chromosomal location.". Genomics 7 (2): 289-93. PMID 2129532. 
  • Zimmermann K, Kautz S, Hajdu G, et al. (1990). "Heterogenic mRNAs with an identical protein-coding region of the human embryonic myosin alkali light chain in skeletal muscle cells.". J. Mol. Biol. 211 (3): 505-13. PMID 2308163. 
  • Seidel U, Bober E, Winter B, et al. (1988). "Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms.". Gene 66 (1): 135-46. PMID 2458299. 
  • Arnold HH, Lohse P, Seidel U, Bober E (1989). "A novel human myosin alkali light chain is developmentally regulated. Expression in fetal cardiac and skeletal muscle and in adult atria.". Eur. J. Biochem. 178 (1): 53-60. PMID 2849544. 
  • Kurabayashi M, Komuro I, Tsuchimochi H, et al. (1988). "Molecular cloning and characterization of human atrial and ventricular myosin alkali light chain cDNA clones.". J. Biol. Chem. 263 (27): 13930-6. PMID 3417683. 
  • Strohman RC, Micou-Eastwood J, Glass CA, Matsuda R (1983). "Human fetal muscle and cultured myotubes derived from it contain a fetal-specific myosin light chain.". Science 221 (4614): 955-7. PMID 6879193. 
  • Timson DJ, Trayer IP (1997). "The rôle of the proline-rich region in A1-type myosin essential light chains: implications for information transmission in the actomyosin complex.". FEBS Lett. 400 (1): 31-6. PMID 9000508. 
  • Timson DJ, Trayer HR, Trayer IP (1998). "The N-terminus of A1-type myosin essential light chains binds actin and modulates myosin motor function.". Eur. J. Biochem. 255 (3): 654-62. PMID 9738905. 
  • Timson DJ, Trayer HR, Smith KJ, Trayer IP (1999). "Size and charge requirements for kinetic modulation and actin binding by alkali 1-type myosin essential light chains.". J. Biol. Chem. 274 (26): 18271-7. PMID 10373429. 
  • Morano I (1999). "Tuning the human heart molecular motors by myosin light chains.". J. Mol. Med. 77 (7): 544-55. PMID 10494800. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863. 
  • Arrell DK, Neverova I, Fraser H, et al. (2001). "Proteomic analysis of pharmacologically preconditioned cardiomyocytes reveals novel phosphorylation of myosin light chain 1.". Circ. Res. 89 (6): 480-7. PMID 11557734. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Abdelaziz AI, Pagel I, Schlegel WP, et al. (2006). "Human atrial myosin light chain 1 expression attenuates heart failure.". Adv. Exp. Med. Biol. 565: 283-92; discussion 92, 405-15. PMID 16106982. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901. 
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