MYH9

From Wikipedia, the free encyclopedia

Myosin, heavy chain 9, non-muscle

Identifiers

MYH9; DFNA17; EPSTS; FTNS; MGC104539; MHA; NMHC-II-A; NMMHCA

External IDs

OMIM: 160775 MGI: 107717 HomoloGene: 68257

Gene ontology
Molecular Function:	• microfilament motor activity • nucleotide binding • motor activity • calmodulin binding • ATP binding • ATPase activity • protein homodimerization activity • protein anchor • actin filament binding
Cellular Component:	• stress fiber • ruffle • nucleus • cytoplasm • contractile ring • cytosol • plasma membrane • cell-cell adherens junction • integrin complex • myosin complex • cleavage furrow
Biological Process:	• cellular morphogenesis during differentiation • cytokinesis • angiogenesis • membrane protein ectodomain proteolysis • integrin-mediated signaling pathway • sensory perception of sound • regulation of cell shape • protein transport • cell-cell adhesion • actin filament-based movement • platelet formation • monocyte differentiation • actin cytoskeleton reorganization • blood vessel endothelial cell migration • leukocyte migration

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002473 (mRNA)
NP_002464 (protein)

NM_181327 (mRNA)
NP_851844 (protein)

Location

Chr 22: 35.01 - 35.11 Mb

Chr 15: 77.59 - 77.67 Mb

Pubmed search

[1]

[2]

Myosin, heavy chain 9, non-muscle, also known as MYH9, is a human gene.

[edit] See also

May Hegglin anomaly

[edit] Further reading

Starr R, Offer G (1978). "The interaction of C-protein with heavy meromyosin and subfragment-2.". Biochem. J. 171 (3): 813–6. PMID 352343.
Lee CL, Atassi MZ (1978). "Enzymic and immunochemical properties of lysozyme. Accurate definition of the antigenic site around the disulphide bridge 30-115 (site 3) by 'surface-simulation' synthesis.". Biochem. J. 167 (3): 571–81. PMID 603622.
Tweed WA, Phua WT, Chong KY, et al. (1992). "Large tidal volume ventilation improves pulmonary gas exchange during lower abdominal surgery in Trendelenburg's position.". Canadian journal of anaesthesia = Journal canadien d'anesthésie 38 (8): 989–95. PMID 1752022.
Simons M, Wang M, McBride OW, et al. (1991). "Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes.". Circ. Res. 69 (2): 530–9. PMID 1860190.
Toothaker LE, Gonzalez DA, Tung N, et al. (1991). "Cellular myosin heavy chain in human leukocytes: isolation of 5' cDNA clones, characterization of the protein, chromosomal localization, and upregulation during myeloid differentiation.". Blood 78 (7): 1826–33. PMID 1912569.
Saez CG, Myers JC, Shows TB, Leinwand LA (1990). "Human nonmuscle myosin heavy chain mRNA: generation of diversity through alternative polyadenylylation.". Proc. Natl. Acad. Sci. U.S.A. 87 (3): 1164–8. PMID 1967836.
Moos C, Feng IN (1980). "Effect of C-protein on actomyosin ATPase.". Biochim. Biophys. Acta 632 (2): 141–9. PMID 6448079.
Obermann WM, Plessmann U, Weber K, Fürst DO (1995). "Purification and biochemical characterization of myomesin, a myosin-binding and titin-binding protein, from bovine skeletal muscle.". Eur. J. Biochem. 233 (1): 110–5. PMID 7588733.
Maupin P, Phillips CL, Adelstein RS, Pollard TD (1995). "Differential localization of myosin-II isozymes in human cultured cells and blood cells.". J. Cell. Sci. 107 ( Pt 11): 3077–90. PMID 7699007.
Bement WM, Hasson T, Wirth JA, et al. (1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6549–53. PMID 8022818.
Eilertsen KJ, Kazmierski ST, Keller TC (1994). "Cellular titin localization in stress fibers and interaction with myosin II filaments in vitro.". J. Cell Biol. 126 (5): 1201–10. PMID 8063857.
Shoeman RL, Sachse C, Höner B, et al. (1993). "Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin.". Am. J. Pathol. 142 (1): 221–30. PMID 8424456.
Lalwani AK, Linthicum FH, Wilcox ER, et al. (1998). "A five-generation family with late-onset progressive hereditary hearing impairment due to cochleosaccular degeneration.". Audiol. Neurootol. 2 (3): 139–54. PMID 9390828.
Ford HL, Silver DL, Kachar B, et al. (1998). "Effect of Mts1 on the structure and activity of nonmuscle myosin II.". Biochemistry 36 (51): 16321–7. doi:10.1021/bi971182l. PMID 9405067.
Obermann WM, van der Ven PF, Steiner F, et al. (1998). "Mapping of a myosin-binding domain and a regulatory phosphorylation site in M-protein, a structural protein of the sarcomeric M band.". Mol. Biol. Cell 9 (4): 829–40. PMID 9529381.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Miyamoto CA, Fischman DA, Reinach FC (2000). "The interface between MyBP-C and myosin: site-directed mutagenesis of the CX myosin-binding domain of MyBP-C.". J. Muscle Res. Cell. Motil. 20 (7): 703–15. PMID 10672519.
Sajid M, Hu Z, Lele M, Stouffer GA (2000). "Protein complexes involving alpha v beta 3 integrins, nonmuscle myosin heavy chain-A, and focal adhesion kinase from in thrombospondin-treated smooth muscle cells.". J. Investig. Med. 48 (3): 190–7. PMID 10822899.
Husi H, Ward MA, Choudhary JS, et al. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.". Nat. Neurosci. 3 (7): 661–9. doi:10.1038/76615. PMID 10862698.
Kelley MJ, Jawien W, Lin A, et al. (2000). "Autosomal dominant macrothrombocytopenia with leukocyte inclusions (May-Hegglin anomaly) is linked to chromosome 22q12-13.". Hum. Genet. 106 (5): 557–64. PMID 10914687.