MYH2

From Wikipedia, the free encyclopedia

Myosin, heavy chain 2, skeletal muscle, adult

Identifiers

MYH2; MYH2A; MYHSA2; MYHas8; MyHC-2A; MyHC-IIa

External IDs

OMIM: 160740 MGI: 1339710 HomoloGene: 75068

Gene ontology
Molecular Function:	• microfilament motor activity • nucleotide binding • motor activity • actin binding • calmodulin binding • ATP binding
Cellular Component:	• muscle myosin complex • striated muscle thick filament • myosin complex
Biological Process:	• striated muscle contraction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_017534 (mRNA)
NP_060004 (protein)

NM_001039545 (mRNA)
NP_001034634 (protein)

Location

Chr 17: 10.37 - 10.39 Mb

Chr 11: 66.99 - 67.01 Mb

Pubmed search

[1]

[2]

Myosin, heavy chain 2, skeletal muscle, adult, also known as MYH2, is a human gene.^[1]

[edit] References

^ Entrez Gene: MYH2 myosin, heavy chain 2, skeletal muscle, adult.

[edit] Further reading

Schwartz CE, McNally E, Leinwand L, Skolnick MH (1987). "A polymorphic human myosin heavy chain locus is linked to an anonymous single copy locus (D17S1) at 17p13.". Cytogenet. Cell Genet. 43 (1-2): 117-20. PMID 2877813.
Smerdu V, Karsch-Mizrachi I, Campione M, et al. (1995). "Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle.". Am. J. Physiol. 267 (6 Pt 1): C1723-8. PMID 7545970.
Ennion S, Sant'ana Pereira J, Sargeant AJ, et al. (1995). "Characterization of human skeletal muscle fibres according to the myosin heavy chains they express.". J. Muscle Res. Cell. Motil. 16 (1): 35-43. PMID 7751403.
Hisatome I, Morisaki T, Kamma H, et al. (1998). "Control of AMP deaminase 1 binding to myosin heavy chain.". Am. J. Physiol. 275 (3 Pt 1): C870-81. PMID 9730972.
Weiss A, McDonough D, Wertman B, et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958-63. PMID 10077619.
Weiss A, Schiaffino S, Leinwand LA (1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.". J. Mol. Biol. 290 (1): 61-75. doi:10.1006/jmbi.1999.2865. PMID 10388558.
Onuoha GN, Alpar EK, Laprade M, et al. (1999). "Effects of bone fracture and surgery on plasma myosin heavy chain fragments of skeletal muscle.". Clinical and investigative medicine. Médecine clinique et experimentale 22 (5): 180-4. PMID 10579056.
Martinsson T, Oldfors A, Darin N, et al. (2001). "Autosomal dominant myopathy: missense mutation (Glu-706 --> Lys) in the myosin heavy chain IIa gene.". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14614-9. doi:10.1073/pnas.250289597. PMID 11114175.
Tajsharghi H, Thornell LE, Darin N, et al. (2002). "Myosin heavy chain IIa gene mutation E706K is pathogenic and its expression increases with age.". Neurology 58 (5): 780-6. PMID 11889243.
England K, Ashford D, Kidd D, Rumsby M (2002). "PKC epsilon is associated with myosin IIA and actin in fibroblasts.". Cell. Signal. 14 (6): 529-36. PMID 11897493.
Allen DL, Leinwand LA (2003). "Intracellular calcium and myosin isoform transitions. Calcineurin and calcium-calmodulin kinase pathways regulate preferential activation of the IIa myosin heavy chain promoter.". J. Biol. Chem. 277 (47): 45323-30. doi:10.1074/jbc.M208302200. PMID 12235157.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kim EJ, Helfman DM (2003). "Characterization of the metastasis-associated protein, S100A4. Roles of calcium binding and dimerization in cellular localization and interaction with myosin.". J. Biol. Chem. 278 (32): 30063-73. doi:10.1074/jbc.M304909200. PMID 12756252.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Chung MC, Kawamoto S (2005). "IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression during phorbol ester-induced promyelocytic HL-60 differentiation.". J. Biol. Chem. 279 (53): 56042-52. doi:10.1074/jbc.M404791200. PMID 15496418.
Tajsharghi H, Darin N, Rekabdar E, et al. (2005). "Mutations and sequence variation in the human myosin heavy chain IIa gene (MYH2).". Eur. J. Hum. Genet. 13 (5): 617-22. doi:10.1038/sj.ejhg.5201375. PMID 15741996.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Li M, Lionikas A, Yu F, et al. (2006). "Muscle cell and motor protein function in patients with a IIa myosin missense mutation (Glu-706 to Lys).". Neuromuscul. Disord. 16 (11): 782-91. doi:10.1016/j.nmd.2006.07.023. PMID 17005402.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.