MYH1

From Wikipedia, the free encyclopedia

Myosin, heavy chain 1, skeletal muscle, adult

PDB rendering based on 1m8q.

Available structures: 1m8q, 1mvw, 1o18, 1o19, 1o1a, 1o1b, 1o1c, 1o1d, 1o1e, 1o1f, 1o1g

Identifiers

Symbol(s)

MYH1; MGC133384; MYHSA1; MYHa; MyHC-2X/D

External IDs

OMIM: 160730 MGI: 1339711 HomoloGene: 68493

Gene ontology
Molecular Function:	• microfilament motor activity • nucleotide binding • motor activity • actin binding • calmodulin binding • ATP binding
Cellular Component:	• muscle myosin complex • striated muscle thick filament • myosin complex
Biological Process:	• striated muscle contraction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005963 (mRNA)
NP_005954 (protein)

NM_030679 (mRNA)
NP_109604 (protein)

Location

Chr 17: 10.34 - 10.36 Mb

Chr 11: 67.02 - 67.04 Mb

Pubmed search

[1]

[2]

Myosin, heavy chain 1, skeletal muscle, adult, also known as MYH1, is a human gene.^[1]

Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development.^[1]

[edit] References

^ ^a ^b Entrez Gene: MYH1 myosin, heavy chain 1, skeletal muscle, adult.

[edit] Further reading

Yoon SJ, Seiler SH, Kucherlapati R, Leinwand L (1993). "Organization of the human skeletal myosin heavy chain gene cluster.". Proc. Natl. Acad. Sci. U.S.A. 89 (24): 12078–82. PMID 1465443.
Saez L, Leinwand LA (1986). "Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle.". Nucleic Acids Res. 14 (7): 2951–69. PMID 2421254.
Leinwand LA, Saez L, McNally E, Nadal-Ginard B (1983). "Isolation and characterization of human myosin heavy chain genes.". Proc. Natl. Acad. Sci. U.S.A. 80 (12): 3716–20. PMID 6304733.
Smerdu V, Karsch-Mizrachi I, Campione M, et al. (1995). "Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle.". Am. J. Physiol. 267 (6 Pt 1): C1723–8. PMID 7545970.
Weiss A, McDonough D, Wertman B, et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. PMID 10077619.
Weiss A, Schiaffino S, Leinwand LA (1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.". J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558.
Daugaard JR, Nielsen JN, Kristiansen S, et al. (2000). "Fiber type-specific expression of GLUT4 in human skeletal muscle: influence of exercise training.". Diabetes 49 (7): 1092–5. PMID 10909963.
Korfage JA, Brugman P, Van Eijden TM (2000). "Intermuscular and intramuscular differences in myosin heavy chain composition of the human masticatory muscles.". J. Neurol. Sci. 178 (2): 95–106. PMID 11018701.
Konig S, Burkman J, Fitzgerald J, et al. (2002). "Modular organization of phylogenetically conserved domains controlling developmental regulation of the human skeletal myosin heavy chain gene family.". J. Biol. Chem. 277 (31): 27593–605. doi:10.1074/jbc.M203162200. PMID 11971910.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Villacé P, Marión RM, Ortín J (2004). "The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs.". Nucleic Acids Res. 32 (8): 2411–20. doi:10.1093/nar/gkh552. PMID 15121898.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Pontén EM, Stål PS (2007). "Decreased capillarization and a shift to fast myosin heavy chain IIx in the biceps brachii muscle from young adults with spastic paresis.". J. Neurol. Sci. 253 (1-2): 25–33. doi:10.1016/j.jns.2006.11.006. PMID 17196619.