Mycothione reductase

From Wikipedia, the free encyclopedia

In enzymology, a mycothione reductase (EC 1.8.1.15) is an enzyme that catalyzes the chemical reaction

mycothione + NAD(P)H + H ⁺ 2 mycothiol + NADP⁺

in M. tuberculosis and other actinomycetes.

The 2 substrates of this enzyme are mycothiol and NADPH, whereas 2 molecules of mycothione and NADP⁺ are formed as products.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is mycothiol:NAD(P)+ oxidoreductase. This enzyme is also called mycothiol-disulfide reductase.

[edit] References

• IUBMB entry for 1.8.1.15
• BRENDA references for 1.8.1.15 (Recommended.)
• PubMed references for 1.8.1.15
• PubMed Central references for 1.8.1.15
• Google Scholar references for 1.8.1.15
• Patel MP, Blanchard JS (1999). "Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase". Biochemistry. 38: 11827–33. doi:10.1021/bi991025h. PMID 10512639. 
• Patel MP, Blanchard JS (2001). "Mycobacterium tuberculosis mycothione reductase: pH dependence of the kinetic parameters and kinetic isotope effects". Biochemistry. 40: 5119–26. doi:10.1021/bi0029144. PMID 11318633. 

[edit] External links

• IUBMB entry for 1.8.1.15

• KEGG entry for 1.8.1.15

• BRENDA entry for 1.8.1.15

• NiceZyme view of 1.8.1.15

• EC2PDB: PDB structures for 1.8.1.15

• PRIAM entry for 1.8.1.15

• PUMA2 entry for 1.8.1.15

• IntEnz: Integrated Enzyme entry for 1.8.1.15

• MetaCyc entry for 1.8.1.15

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050627: mycothione reductase

• AMIGO entry for GO code 0050627: mycothione reductase