Mycothiol-dependent formaldehyde dehydrogenase

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In enzymology, a mycothiol-dependent formaldehyde dehydrogenase (EC 1.2.1.66) is an enzyme that catalyzes the chemical reaction

formaldehyde + mycothiol + NAD⁺ $\rightleftharpoons$ S-formylmycothiol + NADH + 2 H⁺

The 3 substrates of this enzyme are formaldehyde, mycothiol, and NAD⁺, whereas its 3 products are S-formylmycothiol, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is formaldehyde:NAD+ oxidoreductase (mycothiol-formylating). This enzyme is also called NAD/factor-dependent formaldehyde dehydrogenase.

[edit] References

IUBMB entry for 1.2.1.66
BRENDA references for 1.2.1.66 (Recommended.)
PubMed references for 1.2.1.66
PubMed Central references for 1.2.1.66
Google Scholar references for 1.2.1.66
Misset-Smits M, van Ophem PW, Sakuda S, Duine JA (1997). "Mycothiol, 1-O-(2'-[N-acetyl-L-cysteinyl]amido-2'-deoxy-alpha-D-glucopyranosyl) -D- myo-inositol, is the factor of NAD/factor-dependent formaldehyde dehydrogenase". FEBS. Lett. 409: 221–2. doi:10.1016/S0014-5793(97)00510-3. PMID 9202149.
Norin A, Van Ophem PW, Piersma SR, Persson B, Duine JA, Jornvall H (1997). "Mycothiol-dependent formaldehyde dehydrogenase, a prokaryotic medium-chain dehydrogenase/reductase, phylogenetically links different eukaroytic alcohol dehydrogenases--primary structure, conformational modelling and functional correlations". Eur. J. Biochem. 248: 282–9. doi:10.1111/j.1432-1033.1997.00282.x. PMID 9346279.