Mycobacterium intracellulare

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Mycobacterium intracellulare

Scientific classification

Kingdom:	Bacteria
Phylum:	Actinobacteria
Order:	Actinomycetales
Suborder:	Corynebacterineae
Family:	Mycobacteriaceae
Genus:	Mycobacterium
Species:	M. intracellulare

Binomial name

Mycobacterium intracellulare
Runyon 1965, ATCC 13950

Mycobacterium intracellulare

1 Description
2 Pathogenesis
3 Type Strain
4 References

[edit] Description

Gram-positive, nonmotile and acid-fast short to long rods.

Colony characteristics

Usually smooth, rarely rough and nonpigmented colonies. Ageing colonies may become yellow.

Physiology

Growth on Löwenstein-Jensen medium and Middlebrook 7H10 at 37°C after 7 or more days.
Resistant to isoniazid, ethambutol, rifampin and streptomycin.

Differential characteristics

M. intracellulare and Mycobacterium avium form the M. avium-intracellulare complex (MAIC). A commercially available hybridisation assay (AccuProbe) to identify all members of the MAIC exists. Furthermore, separate AccuProbes are available to identify either M. intracellulare or M. avium.
Remarkable ITS heterogeneity within different M. intracellulare isolates.

[edit] Pathogenesis

Most frequently encountered in pulmonary secretions from patients suffering from tuberculosis-like disease and from surgical specimens from such patients.
When isolated from human secretions, it is often the etiologic agent of pulmonary disease, although frequently isolated as apparent casual resident
Biosafety level 2

[edit] Type Strain

First isolated from fatal systemic disease in a child. Found in soil and water.

Strain ATCC 13950 = CCUG 28005 = CIP 104243 = DSM 43223 = JCM 6384 = NCTC 13025.

[edit] References

Cuttino, J., A. McCabe. 1949. Pure granulomatous nocardiosis: A new fungus disease distinguished by intracellular parasitism. American Journal of Clinical Pathology, 25, 1-34.
Runyon, E. 1965. Pathogenic mycobacteria. Advances in Tuberculosis Research, 14, 235-287.