Mycobacterium haemophilum

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Mycobacterium haemophilum

Scientific classification

Kingdom:	Bacteria
Phylum:	Actinobacteria
Order:	Actinomycetales
Suborder:	Corynebacterineae
Family:	Mycobacteriaceae
Genus:	Mycobacterium
Species:	M. haemophilum

Binomial name

Mycobacterium haemophilum
Sompolinsky et al. 1978, ATCC 29548

Mycobacterium haemophilum

1 Description
2 Pathogenesis
3 Type Strain
4 References

[edit] Description

Short, occasionally curved, gram-positive, nonmotile and strongly acid-fast rods.

Colony characteristics

Nonpigmented and rough to smooth colonies.

Physiology

Media have to be supplemented with 0.4% haemoglobin or 60µM hemin (factor X) or 15mg/ml ferric ammonium citrate respectively, but not with FeCl3 or catalase.
Slow growth on Löwenstein-Jensen media or Middlebrook 7H10 agar at 32°C within 2-4 weeks.
Growth slower at 25°C and 35°C and absent at 37°C.
Strictly intracellular growth in tissue cultures of fibroblasts.

Differential characteristics

Unique among mycobacteria in its requirement for hemin or ferric ammonium citrate for growth.

Distribution.

[edit] Pathogenesis

Infects patients with suppressed immune systems.
Clinical presentation: multiple skin nodules occurring in clusters or without definitive pattern, commonly involving the extremities. Abscesses, draining fistulas and osteomyelitis may be associated with the nodules. Paediatric patients with localised cervical lymphadenopathy.
Biosafety level 2

[edit] Type Strain

First isolated in Israel from a subcutaneous granuloma from a patient with Hodgkin's disease. An environmental reservoir is presumed. Strain ATCC 29548 = CCUG 47452 = CIP 105049 = DSM 44634 = NCTC 11185.

[edit] References

Sompolinsky et al. 1978. Mycobacterium haemophilum sp. nov., a new pathogen of humans. International Journal of Systematic Bacteriology, 28, 67-75.