MYCBP

From Wikipedia, the free encyclopedia

C-myc binding protein

Identifiers

External IDs

OMIM: 606535 MGI: 1891750 HomoloGene: 49312

Gene ontology
Molecular Function:	• transcription coactivator activity • protein binding
Cellular Component:	• nucleus • cytoplasm • mitochondrion
Biological Process:	• transcription • regulation of transcription, DNA-dependent

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_012333 (mRNA)
NP_036465 (protein)

NM_019660 (mRNA)
NP_062634 (protein)

Location

n/a

Chr 4: 123.41 - 123.41 Mb

Pubmed search

[1]

[2]

C-myc binding protein, also known as MYCBP, is a human gene.^[1]

The MYCBP gene encodes a protein that binds to the N-terminal region of MYC (MIM 190080) and stimulates the activation of E box-dependent transcription by MYC.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: MYCBP c-myc binding protein.

[edit] Further reading

Taira T, Maëda J, Onishi T, et al. (1998). "AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC.". Genes Cells 3 (8): 549–65. PMID 9797456.
Furusawa M, Ohnishi T, Taira T, et al. (2001). "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase.". J. Biol. Chem. 276 (39): 36647–51. doi:10.1074/jbc.M103885200. PMID 11483602.
Yukitake H, Furusawa M, Taira T, et al. (2002). "AMAP-1, a novel testis-specific AMY-1-binding protein, is differentially expressed during the course of spermatogenesis.". Biochim. Biophys. Acta 1577 (1): 126–32. PMID 12151104.
Yukitake H, Furusawa M, Taira T, et al. (2003). "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase.". J. Biol. Chem. 277 (47): 45480–92. doi:10.1074/jbc.M206201200. PMID 12223483.
Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (2003). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex.". J. Biol. Chem. 277 (52): 50885–92. doi:10.1074/jbc.M206387200. PMID 12414807.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tomsig JL, Snyder SL, Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.". J. Biol. Chem. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ishizaki R, Shin HW, Iguchi-Ariga SM, et al. (2006). "AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors.". Genes Cells 11 (8): 949–59. doi:10.1111/j.1365-2443.2006.00991.x. PMID 16866877.
Sedoris KC, Thomas SD, Miller DM (2007). "c-myc promoter binding protein regulates the cellular response to an altered glucose concentration.". Biochemistry 46 (29): 8659–68. doi:10.1021/bi7003558. PMID 17595061.