MYB

From Wikipedia, the free encyclopedia


V-myb myeloblastosis viral oncogene homolog (avian)
PDB rendering based on 1guu.
Available structures: 1guu, 1gv2, 1gv5, 1gvd, 1h88, 1h89, 1h8a, 1idy, 1idz, 1mbe, 1mbf, 1mbg, 1mbh, 1mbj, 1mbk, 1mse, 1msf
Identifiers
Symbol(s) MYB; Cmyb; c-myb; c-myb_CDS; efg
External IDs OMIM: 189990 MGI: 97249 HomoloGene: 31311
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4602 17863
Ensembl ENSG00000118513 ENSMUSG00000019982
Uniprot P10242 Q8BU24
Refseq NM_005375 (mRNA)
NP_005366 (protein)		 NM_033597 (mRNA)
NP_291075 (protein)
Location Chr 6: 135.54 - 135.58 Mb Chr 10: 20.82 - 20.85 Mb
Pubmed search [1] [2]

V-myb myeloblastosis viral oncogene homolog (avian), also known as MYB, is a human gene.


[edit] Further reading

  • Oh IH, Reddy EP (1999). "The myb gene family in cell growth, differentiation and apoptosis.". Oncogene 18 (19): 3017–33. doi:10.1038/sj.onc.1202839. PMID 10378697. 
  • Nicolaides NC, Gualdi R, Casadevall C, et al. (1991). "Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb gene.". Mol. Cell. Biol. 11 (12): 6166–76. PMID 1944282. 
  • Kalkbrenner F, Guehmann S, Moelling K (1990). "Transcriptional activation by human c-myb and v-myb genes.". Oncogene 5 (5): 657–61. PMID 2189102. 
  • Westin EH, Gorse KM, Clarke MF (1990). "Alternative splicing of the human c-myb gene.". Oncogene 5 (8): 1117–24. PMID 2202948. 
  • Dasgupta P, Reddy EP (1990). "Identification of alternatively spliced transcripts for human c-myb: molecular cloning and sequence analysis of human c-myb exon 9A sequences.". Oncogene 4 (12): 1419–23. PMID 2687764. 
  • Janssen JW, Vernole P, de Boer PA, et al. (1986). "Sublocalization of c-myb to 6q21----q23 by in situ hybridization and c-myb expression in a human teratocarcinoma with 6q rearrangements.". Cytogenet. Cell Genet. 41 (3): 129–35. PMID 3007038. 
  • Slamon DJ, Boone TC, Murdock DC, et al. (1986). "Studies of the human c-myb gene and its product in human acute leukemias.". Science 233 (4761): 347–51. PMID 3014652. 
  • Majello B, Kenyon LC, Dalla-Favera R (1987). "Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus.". Proc. Natl. Acad. Sci. U.S.A. 83 (24): 9636–40. PMID 3540945. 
  • Szczylik C, Skorski T, Ku DH, et al. (1993). "Regulation of proliferation and cytokine expression of bone marrow fibroblasts: role of c-myb.". J. Exp. Med. 178 (3): 997–1005. PMID 7688794. 
  • Krieg J, Oelgeschläger M, Janknecht R, Lüscher B (1995). "High affinity DNA binding of native full length c-Myb and differential proteolytic sensitivity of its N- and C-terminal domains.". Oncogene 10 (11): 2221–8. PMID 7784067. 
  • Jacobs SM, Gorse KM, Westin EH (1994). "Identification of a second promoter in the human c-myb proto-oncogene.". Oncogene 9 (1): 227–35. PMID 8302584. 
  • Favier D, Gonda TJ (1994). "Detection of proteins that bind to the leucine zipper motif of c-Myb.". Oncogene 9 (1): 305–11. PMID 8302594. 
  • Glaser R, Lafuse WP, Bonneau RH, et al. (1993). "Stress-associated modulation of proto-oncogene expression in human peripheral blood leukocytes.". Behav. Neurosci. 107 (3): 525–9. PMID 8329139. 
  • Dash AB, Orrico FC, Ness SA (1996). "The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb.". Genes Dev. 10 (15): 1858–69. PMID 8756344. 
  • Vorbrueggen G, Lovrić J, Moelling K (1997). "Functional analysis of phosphorylation at serine 532 of human c-Myb by MAP kinase.". Biol. Chem. 377 (11): 721–30. PMID 8960373. 
  • Tavner FJ, Simpson R, Tashiro S, et al. (1998). "Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb.". Mol. Cell. Biol. 18 (2): 989–1002. PMID 9447996. 
  • Hedge SP, Kumar A, Kurschner C, Shapiro LH (1998). "c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation.". Mol. Cell. Biol. 18 (5): 2729–37. PMID 9566892. 
  • Leverson JD, Koskinen PJ, Orrico FC, et al. (1998). "Pim-1 kinase and p100 cooperate to enhance c-Myb activity.". Mol. Cell 2 (4): 417–25. PMID 9809063. 
  • Thompson MA, Rosenthal MA, Ellis SL, et al. (1998). "c-Myb down-regulation is associated with human colon cell differentiation, apoptosis, and decreased Bcl-2 expression.". Cancer Res. 58 (22): 5168–75. PMID 9823328. 
  • Verbeek W, Gombart AF, Chumakov AM, et al. (1999). "C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters.". Blood 93 (10): 3327–37. PMID 10233885. 

[edit] External links


 This article on a gene on chromosome 6 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD