MYBL2

From Wikipedia, the free encyclopedia


V-myb myeloblastosis viral oncogene homolog (avian)-like 2
PDB rendering based on 1a5j.
Available structures: 1a5j, 2d9a
Identifiers
Symbol(s) MYBL2; B-MYB; BMYB; MGC15600
External IDs OMIM: 601415 MGI: 101785 HomoloGene: 1847
Orthologs
Human Mouse
Entrez 4605 17865
Ensembl ENSG00000101057 ENSMUSG00000017861
Uniprot P10244 P48972
Refseq NM_002466 (mRNA)
NP_002457 (protein)		 NM_008652 (mRNA)
NP_032678 (protein)
Location Chr 20: 41.73 - 41.78 Mb Chr 2: 162.75 - 162.78 Mb
Pubmed search [1] [2]

V-myb myeloblastosis viral oncogene homolog (avian)-like 2, also known as MYBL2, is a human gene.

The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.[1]

[edit] References

  1. ^ Entrez Gene: MYBL2 v-myb myeloblastosis viral oncogene homolog (avian)-like 2.

[edit] Further reading

  • Golay J, Cusmano G, Introna M (1992). "Independent regulation of c-myc, B-myb, and c-myb gene expression by inducers and inhibitors of proliferation in human B lymphocytes.". J. Immunol. 149 (1): 300–8. PMID 1376749. 
  • Reiss K, Travali S, Calabretta B, Baserga R (1991). "Growth regulated expression of B-myb in fibroblasts and hematopoietic cells.". J. Cell. Physiol. 148 (3): 338–43. doi:10.1002/jcp.1041480303. PMID 1717494. 
  • Golay J, Capucci A, Arsura M, et al. (1991). "Expression of c-myb and B-myb, but not A-myb, correlates with proliferation in human hematopoietic cells.". Blood 77 (1): 149–58. PMID 1984793. 
  • Nomura N, Takahashi M, Matsui M, et al. (1989). "Isolation of human cDNA clones of myb-related genes, A-myb and B-myb.". Nucleic Acids Res. 16 (23): 11075–89. PMID 3060855. 
  • Lam EW, Bennett JD, Watson RJ (1995). "Cell-cycle regulation of human B-myb transcription.". Gene 160 (2): 277–81. PMID 7642110. 
  • Takemoto Y, Tashiro S, Handa H, Ishii S (1994). "Multiple nuclear localization signals of the B-myb gene product.". FEBS Lett. 350 (1): 55–60. PMID 8062924. 
  • Zhou W, Takuwa N, Kumada M, Takuwa Y (1994). "E2F1, B-myb and selective members of cyclin/cdk subunits are targets for protein kinase C-mediated bimodal growth regulation in vascular endothelial cells.". Biochem. Biophys. Res. Commun. 199 (1): 191–8. doi:10.1006/bbrc.1994.1213. PMID 8123011. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Arsura M, Luchetti MM, Erba E, et al. (1994). "Dissociation between p93B-myb and p75c-myb expression during the proliferation and differentiation of human myeloid cell lines.". Blood 83 (7): 1778–90. PMID 8142646. 
  • Nakagoshi H, Takemoto Y, Ishii S (1993). "Functional domains of the human B-myb gene product.". J. Biol. Chem. 268 (19): 14161–7. PMID 8314782. 
  • Noben-Trauth K, Copeland NG, Gilbert DJ, et al. (1996). "Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q 13.1.". Genomics 35 (3): 610–2. doi:10.1006/geno.1996.0408. PMID 8812502. 
  • Sala A, Kundu M, Casella I, et al. (1997). "Activation of human B-MYB by cyclins.". Proc. Natl. Acad. Sci. U.S.A. 94 (2): 532–6. PMID 9012818. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Saville MK, Watson RJ (1998). "The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties.". Oncogene 17 (21): 2679–89. doi:10.1038/sj.onc.1202503. PMID 9840932. 
  • Bartsch O, Horstmann S, Toprak K, et al. (1999). "Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb.". Eur. J. Biochem. 260 (2): 384–91. PMID 10095772. 
  • Kim T, Jung H, Min S, et al. (1999). "B-myb proto-oncogene products interact in vivo with each other via the carboxy-terminal conserved region.". FEBS Lett. 460 (2): 363–8. PMID 10544265. 
  • Johnson TK, Schweppe RE, Septer J, Lewis RE (2000). "Phosphorylation of B-Myb regulates its transactivation potential and DNA binding.". J. Biol. Chem. 274 (51): 36741–9. PMID 10593981. 
  • Horstmann S, Ferrari S, Klempnauer KH (2000). "Regulation of B-Myb activity by cyclin D1.". Oncogene 19 (2): 298–306. doi:10.1038/sj.onc.1203302. PMID 10645009. 
  • De Falco G, Bagella L, Claudio PP, et al. (2000). "Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation.". Oncogene 19 (3): 373–9. doi:10.1038/sj.onc.1203305. PMID 10656684. 
  • Cervellera MN, Sala A (2000). "Poly(ADP-ribose) polymerase is a B-MYB coactivator.". J. Biol. Chem. 275 (14): 10692–6. PMID 10744766. 

[edit] External links


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD