MXD1

From Wikipedia, the free encyclopedia

MAX dimerization protein 1

PDB rendering based on 1nlw.

Available structures: 1nlw

Identifiers

Symbol(s)

MXD1; MAD; MAD1; MGC104659

External IDs

OMIM: 600021 MGI: 96908 HomoloGene: 1767

Gene ontology
Molecular Function:	• transcription factor activity • transcription corepressor activity • protein binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • multicellular organismal development • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002357 (mRNA)
NP_002348 (protein)

NM_010751 (mRNA)
NP_034881 (protein)

Location

Chr 2: 70 - 70.02 Mb

Chr 6: 86.62 - 86.63 Mb

Pubmed search

[1]

[2]

MAX dimerization protein 1, also known as MXD1, is a human gene.^[1]

MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor.^[1]

[edit] References

^ ^a ^b Entrez Gene: MXD1 MAX dimerization protein 1.

[edit] Further reading

Grandori C, Cowley SM, James LP, Eisenman RN (2001). "The Myc/Max/Mad network and the transcriptional control of cell behavior.". Annu. Rev. Cell Dev. Biol. 16: 653-99. doi:10.1146/annurev.cellbio.16.1.653. PMID 11031250.
Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network.". Gene 277 (1-2): 1-14. PMID 11602341.
Shapiro DN, Valentine V, Eagle L, et al. (1995). "Assignment of the human MAD and MXI1 genes to chromosomes 2p12-p13 and 10q24-q25.". Genomics 23 (1): 282-5. doi:10.1006/geno.1994.1496. PMID 7829091.
Ayer DE, Lawrence QA, Eisenman RN (1995). "Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3.". Cell 80 (5): 767-76. PMID 7889570.
Edelhoff S, Ayer DE, Zervos AS, et al. (1994). "Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19.". Oncogene 9 (2): 665-8. PMID 8290278.
Ayer DE, Kretzner L, Eisenman RN (1993). "Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity.". Cell 72 (2): 211-22. PMID 8425218.
Hassig CA, Fleischer TC, Billin AN, et al. (1997). "Histone deacetylase activity is required for full transcriptional repression by mSin3A.". Cell 89 (3): 341-7. PMID 9150133.
Laherty CD, Yang WM, Sun JM, et al. (1997). "Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression.". Cell 89 (3): 349-56. PMID 9150134.
Gupta K, Anand G, Yin X, et al. (1998). "Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc.". Oncogene 16 (9): 1149-59. doi:10.1038/sj.onc.1201634. PMID 9528857.
FitzGerald MJ, Arsura M, Bellas RE, et al. (1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc.". Oncogene 18 (15): 2489-98. doi:10.1038/sj.onc.1202611. PMID 10229200.
Khan MM, Nomura T, Kim H, et al. (2001). "Role of PML and PML-RARalpha in Mad-mediated transcriptional repression.". Mol. Cell 7 (6): 1233-43. PMID 11430826.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Nikiforov MA, Popov N, Kotenko I, et al. (2003). "The Mad and Myc basic domains are functionally equivalent.". J. Biol. Chem. 278 (13): 11094-9. doi:10.1074/jbc.M212298200. PMID 12538578.
Nair SK, Burley SK (2003). "X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors.". Cell 112 (2): 193-205. PMID 12553908.
Siegel PM, Shu W, Massagué J (2003). "Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression.". J. Biol. Chem. 278 (37): 35444-50. doi:10.1074/jbc.M301413200. PMID 12824180.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.
Zada AA, Pulikkan JA, Bararia D, et al. (2007). "Proteomic discovery of Max as a novel interacting partner of C/EBPalpha: a Myc/Max/Mad link.". Leukemia 20 (12): 2137-46. doi:10.1038/sj.leu.2404438. PMID 17082780.