MX2

From Wikipedia, the free encyclopedia

Myxovirus (influenza virus) resistance 2 (mouse)

Identifiers

MX2; MXB

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • GTP binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• defense response • immune response • response to virus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_002463 (mRNA)
NP_002454 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 21: 41.66 - 41.7 Mb

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Pubmed search

[1]

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Myxovirus (influenza virus) resistance 2 (mouse), also known as MX2, is a human gene.^[1]

The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1.^[1]

[edit] References

^ ^a ^b Entrez Gene: MX2 myxovirus (influenza virus) resistance 2 (mouse).

[edit] Further reading

Horisberger MA, McMaster GK, Zeller H, et al. (1990). "Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter.". J. Virol. 64 (3): 1171–81. PMID 2154602.
Aebi M, Fäh J, Hurt N, et al. (1990). "cDNA structures and regulation of two interferon-induced human Mx proteins.". Mol. Cell. Biol. 9 (11): 5062–72. PMID 2481229.
Horisberger MA, Wathelet M, Szpirer J, et al. (1988). "cDNA cloning and assignment to chromosome 21 of IFI-78K gene, the human equivalent of murine Mx gene.". Somat. Cell Mol. Genet. 14 (2): 123–31. PMID 3162334.
Melén K, Keskinen P, Ronni T, et al. (1996). "Human MxB protein, an interferon-alpha-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope.". J. Biol. Chem. 271 (38): 23478–86. PMID 8798556.
al-Masri AN, Werfel T, Jakschies D, von Wussow P (1997). "Intracellular staining of Mx proteins in cells from peripheral blood, bone marrow and skin.". MP, Mol. Pathol. 50 (1): 9–14. PMID 9208807.
Melén K, Julkunen I (1998). "Nuclear cotransport mechanism of cytoplasmic human MxB protein.". J. Biol. Chem. 272 (51): 32353–9. PMID 9405443.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Tanaka S, Honda Y, Honda M (2007). "Identification of differentially expressed genes in blood cells of narcolepsy patients.". Sleep 30 (8): 974–9. PMID 17702266.