Talk:Muscular dystrophy
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[edit] MD
MD is a collection of twenty or more disorders. I question some of the generalizations here, such as the "Cause" -- not sure that is universal, though I'm no expert. Mine (FSH) has a genetic "cause," though calcium buildup may result causing cell damage. Just a comment/question.
[edit] Copyright free source
I'm using parts of the US Federal Government's 2006 Report to Congress almost verbatim to help flesh out the MD article with decent citations. As a Federal Government report it is copyright free. Verbatim use will help ensure accuracy. see Wikipedia:Copyright_FAQ#Public_domain for more info about public domain works. Theflyer 21:19, 29 July 2007 (UTC)
[edit] Continuation of disease
Why hasn't the disease died out yet? Do female carriers of a dystrophin mutation have some competitive advantage? AxelBoldt 13:41, 25 Jun 2004 (UTC)
Most identified causes for muscular dystrophy are mutations in the gene for the protein dystrophin. It is a huge gene so there are potentially hundreds of distinct mutations that could cause muscular dystrophy (MD). For the best characterized mutations it is recessive and consists of frameshift, early termination, exon skipping, or complete gene knockout. Some of these mutations may be easier to find a cure for than others.
[edit] Genetic disorders never die out.
There will always be new mutations creating new copies of the defective gene. The odds of mutation in a given gene rise directly in proportion with its size. Since the gene in question is very large, it has a relatively large frequency of mutation. While some genetic disorders (such as sickle cell anemia) have selective advantages which increase their allele frequency above that expected from the basal mutation rate, this characteristic is not required for recessive lethal mutations to propagate.
[edit] history
How did this all start? Is there any history on MD? What happened a long time ago? Any help? lol
[edit] Sarcoglycanopathies
I am by no means a doctor, but muscular dytropy is not to my knowledge an infectious disease. Thus, surely either this link is inappropriate or the stub it leads to is inaccurately categorised. I suspect the latter or surely visitors to this page would have noticed. If anyone can suggest more appropriate categories I'd be happy to insert them. I will also alert the robot that created these categories. The Sarcoglycanopathies page itself is sleepy, hence my note here. Ben MacDui (Talk) 10:13, 25 November 2006 (UTC)
- I'm not at all familiar with said disease, but from the description in the article, I agree it doesn't sound in any way infectious. My 'bot restubbed it on the basis of the existing category, which was altered in this earlier edit. I've removed the permcat, and changed the stub template back to {{disease-stub}}. Alai 12:12, 25 November 2006 (UTC)
Sarcoglycanopathies? no where could I find that this has anything to do with Muscular dystrophy and I agree with Alai, Muscular Dystrophy is not infectious and can only be inherited Chad19r 3:20, 26 November 2006 (UTC)
[edit] Filled in alot of Info
I have Muscular Dystrophy and took the time to add a few sections Symptoms, Diagnosis, and Prognosis, among various cleanup and hopefully you'll all feel that it is up to par with what is needed, and hopefully we can end up with a article that'll be the most informative. Chad19r 19:35, 25 November 2006 (UTC)
Material I have added is originally from different public domain documents and some original material references sited at bottom in page I found tons info around the sites and condensed as much as I could without being overdone in this article I hope it sounds good to everyone Chad19r 3:25, 26 November 2006 (UTC)
[edit] Cause section inaccurate
The cause section on this article is inaccurate. Not ALL muscular dystrophies are X-linked. Definitely Duchenne and Becker's are, but many are not (i.e. they are on other chromosomes). I am in the middle of studying for med school exams so I don't have time to edit that section right now, think somebody else can? I'll try to get to it later if I remember... Wilk 54 03:32, 12 December 2006 (UTC)
I've had a quick go at it, though I've introduced a redundancy about manifesting carriers (there doesn't seem to be a Wikipedia article for 'manifesting carrier', incidentally--is another term preferred overseas?). It still needs work. The inheritance patterns for MD are rather interesting, I think; according to my neurologist there is even at least one autosommal dominant form of LGMD. I will try to remember to come back to this article when I'm in a less genetics-enthusiast frame of mind. The Gilly 01:38, 19 December 2006 (UTC)
[edit] Possible treatment for Marfan syndrome & Duchenne
Researchers at Johns Hopkins have shown that a drug commonly used to lower blood pressure reverses muscle wasting in genetically engineered mice with Marfan syndrome and also prevents muscle degeneration in mice with Duchenne muscular dystrophy. [1] Brian Pearson 03:19, 23 January 2007 (UTC)
[edit] Types
While there are over 30 types of MD, only nine are officially classified as MD. How did the remaining get "Generally Classified as MD?" Does anyone have a source we can use to describe how these others were added and why? After I created the MD template and added it to all the pages, a number of editors of those other pages have removed the template, which seems to indicate those interested in the other diseases don't feel they are part of the MD camp? Is the inclusion of these additional diseases just politics to help organizations increase the base of potential donors? See also the discussion occurring at Talk:Hypokalemia#Relationship of Hypokalemia and Muscular Dystrophy. -- Theflyer 14:01, 10 March 2007 (UTC)
- I wikified all the diseases you listed [on Template:Muscular Dystrophy] that already had pages. You might want to make the list match up closely with the Muscular Dystrophy Association page, or keep an eye on it to see if new pages come around for the redlinked diseases.--CastAStone|(talk) 18:31, 23 March 2007 (UTC)
- CastAStone, thanks for creating/linking these other disease pages. I'd still like to do a better job of sourcing the diseases classified as MD and not rely solely on a list of diseases that MDA "targets". My reasoning for this position is that since MDA requires funds, and thus requires ongoing fund raising efforts, their decision to include certain diseases may not always be because they are strictly Muscular Dystrophy. I have not yet run across a citation providing a list of diseases (beyond the nine official forms of MD) that fall inside the umbrella of MD. My thinking is that we should keep the template to only those diseases that are muscular dystrophy, but I'm open to hearing arguments for a different approach. Theflyer 22:37, 26 March 2007 (UTC)
- Not being a medical scientist, I cannot be sure, but I think these additional conditions are not generally considered as 'types of MD' although they bear some resemblance to it. I will attempt to amend this. A new user just changed the total number of 'diseases' in the lead. I can't see an obvious citation to agree with this so I will amend that too. Ben MacDui (Talk) 19:25, 9 April 2007 (UTC)
- The muscular dystrophy template is being overused - polymyositis is not a muscular dystrophy. --Coroebus 13:14, 17 April 2007 (UTC)
- Coroebus, I've retitled the section on the template to say "Diseases with similarities to muscular dystrophy". Theflyer 13:47, 22 April 2007 (UTC)
- That's still problematic. The template should only cover conditions that are classified as MD by a reliable source, and other other conditions should be deleted from the template. Two good sources are the World Health Organization's ICD-10 (example here) and the United States National Library of Medicine's MeSH (example here). --Arcadian 19:50, 22 April 2007 (UTC)
- Coroebus, I've retitled the section on the template to say "Diseases with similarities to muscular dystrophy". Theflyer 13:47, 22 April 2007 (UTC)
- The muscular dystrophy template is being overused - polymyositis is not a muscular dystrophy. --Coroebus 13:14, 17 April 2007 (UTC)
- Not being a medical scientist, I cannot be sure, but I think these additional conditions are not generally considered as 'types of MD' although they bear some resemblance to it. I will attempt to amend this. A new user just changed the total number of 'diseases' in the lead. I can't see an obvious citation to agree with this so I will amend that too. Ben MacDui (Talk) 19:25, 9 April 2007 (UTC)
- CastAStone, thanks for creating/linking these other disease pages. I'd still like to do a better job of sourcing the diseases classified as MD and not rely solely on a list of diseases that MDA "targets". My reasoning for this position is that since MDA requires funds, and thus requires ongoing fund raising efforts, their decision to include certain diseases may not always be because they are strictly Muscular Dystrophy. I have not yet run across a citation providing a list of diseases (beyond the nine official forms of MD) that fall inside the umbrella of MD. My thinking is that we should keep the template to only those diseases that are muscular dystrophy, but I'm open to hearing arguments for a different approach. Theflyer 22:37, 26 March 2007 (UTC)
[edit] WikiProject class rating
This article was automatically assessed because at least one WikiProject had rated the article as start, and the rating on other projects was brought up to start class. BetacommandBot 16:30, 10 November 2007 (UTC)
