Murid herpesvirus 68
From Wikipedia, the free encyclopedia
| Murid herpesvirus 68 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Virus classification | ||||||||||||
|
Murid herpesvirus 68 (MuHV 68) is a subspecies of Murid herpesvirus 4 which is a virus in the genus Rhadinovirus. It is a member of in the subfamily Gammaherpesvirinae in the family Herpesviridae. It is also known as Murine Gammaherpesvirus 68 and MHV-68. MHV-68 serves as a model for study of human gamma-herpesviruses which cause significant human disease including B-cell lymphoma and Kaposi's sarcoma.
[edit] MuHV 68 surface proteins
Alpha-, beta-, and gammaherpesviruses display a heterodimer composed of glycoprotein H (gH) and glycoprotein L (gL) on their envelopes. This receptor is involved in the cell-to-cell transmission of the virus. Glycoprotein H has two conformations. Glycoprotein L is a chaperone protein which assures that gH takes on the correct conformation. When herpesviruses lack gL, gH misfolds. When alpha- or betaherpesviruses lack gL, they are noninfectious. When Murine Gammaherpesvirus 68 lacks gL, it remains infectious but is less able to bind to fibroblasts and epithelial cells. [1]
The open reading frame M7 of the MHV-68 genome encodes for the surface receptor glycoprotein 150 (gp150). It is homologous to the Epstein-Barr virus membrane antigen gp350/220.[2] MHV-68 is more closely related to the Kaposi Sarcoma-associated herpesvirus (KSHV) than it is to the Epstein-Barr virus. Glycoprotein K8.1 is the KSHV homolog of MHV-68 gp150. [3] MHV-68 is a very close relative of MHV-72. The MHV-68 M7 gene differs from the corresponding MHV-72 gene by five point mutations which alter four codons. [2] Glycoprotein 150 allows MHV-68 to bind to B-cells. [3]
[edit] References
- ^ Laurent Gillet, Janet S. May, Susanna Colaco, and Philip G. Stevenson. "Glycoprotein L Disruption Reveals Two Functional Forms of the Murine Gammaherpesvirus 68 Glycoprotein H". Journal of Virology January 2007, p. 280-291, Vol. 81, No. 1.
- ^ a b Macáková K, Matis J, Rezuchová I, Kúdela O, Raslová H, Kúdelová M. "Murine gammaherpesvirus (MHV) M7 gene encoding glycoprotein 150 (gp150): difference in the sequence between 72 and 68 strains". Virus Genes 2003 Jan;26(1):89-95. PMID 12683351.
- ^ a b James P. Stewart, Ondine J. Silvia, Isobel M. D. Atkin, David J. Hughes, Bahram Ebrahimi, and Heiko Adler. "In Vivo Function of a Gammaherpesvirus Virion Glycoprotein: Influence on B-Cell Infection and Mononucleosis". Journal of Virology October 2004, p. 10449-10459, Vol. 78, No. 19.
