Murid herpesvirus 4
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Murid herpesvirus 4 (MuHV 4) is a virus in the genus Rhadinovirus. It is a member of in the subfamily Gammaherpesvirinae in the family Herpesviridae. MuHV 4 infects mice via the nasal passages and causes an acute infectious mononucleosis-like syndrome with elevated levels of leukocytes, and shifts in the relative proportion of lymphocytes along with the appearance of atypical mononuclear cells. [1] Murid herpesvirus 4 currently serves as a model for study of human gamma-herpesvirus pathogenesis. [2]
Seven strains of MuHV 4 have been isolated, including the following six:
- MHV-Šum
- MHV-60
- MHV-68
- MHV-72
- MHV-76
- MHV-4556
[edit] References
- ^ Jela Mistríková, and Július Rajčáni. "Comparison of pathogenic properties of the murid gammaherpesvirus (MuHV 4) strains: a role for immunomodulatory proteins encoded by the left (5'-)end of the genome". Central European Journal of Biology Volume 3, Number 1 / March, 2008.
- ^ Valovicová M, Rezuchorá I, Macáková K, Petrová P, Matis J, Kúdelová M (2006). "Murine gammaherpesvirus (MHV) MK3 gene sequence diversity among 72, 4556, and 68 strains". Virus Genes 2006 Aug;33(1):51-8: 51. doi:. PMID 16791419.
