Multisynthetase complex auxiliary component p38

From Wikipedia, the free encyclopedia


JTV1 gene
Identifiers
Symbol(s) JTV1; AIMP2; P38; PRO0992
External IDs OMIM: 600859 MGI: 2385237 HomoloGene: 4594
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7965 231872
Ensembl ENSG00000106305 ENSMUSG00000029610
Uniprot Q13155 n/a
Refseq NM_006303 (mRNA)
NP_006294 (protein)		 NM_146165 (mRNA)
NP_666277 (protein)
Location Chr 7: 6.02 - 6.03 Mb Chr 5: 144.16 - 144.17 Mb
Pubmed search [1] [2]

JTV1 gene, also known as JTV1, is a human gene.[1]

The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown.[1]

[edit] References

  1. ^ a b Entrez Gene: JTV1 JTV1 gene.

[edit] Further reading

  • Park SG, Ewalt KL, Kim S (2005). "Functional expansion of aminoacyl-tRNA synthetases and their interacting factors: new perspectives on housekeepers.". Trends Biochem. Sci. 30 (10): 569–74. doi:10.1016/j.tibs.2005.08.004. PMID 16125937. 
  • Raszewski W (1978). "Protective action of series of new mono-pyridinium salts and their effect on "aging" of acetylcholine esterase inhibited by fluostigmine.". Polish journal of pharmacology and pharmacy 29 (6): 603–7. PMID 600859. 
  • Norcum MT (1991). "Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents.". J. Biol. Chem. 266 (23): 15398–405. PMID 1651330. 
  • Nicolaides NC, Kinzler KW, Vogelstein B (1996). "Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene.". Genomics 29 (2): 329–34. doi:10.1006/geno.1995.9997. PMID 8666379. 
  • Quevillon S, Robinson JC, Berthonneau E, et al. (1999). "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein.". J. Mol. Biol. 285 (1): 183–95. doi:10.1006/jmbi.1998.2316. PMID 9878398. 
  • Kang J, Kim T, Ko YG, et al. (2000). "Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases.". J. Biol. Chem. 275 (41): 31682–8. doi:10.1074/jbc.M909965199. PMID 10913161. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205. 
  • Ahn HC, Kim S, Lee BJ (2003). "Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43.". FEBS Lett. 542 (1-3): 119–24. PMID 12729910. 
  • Corti O, Hampe C, Koutnikova H, et al. (2004). "The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.". Hum. Mol. Genet. 12 (12): 1427–37. PMID 12783850. 
  • Kim MJ, Park BJ, Kang YS, et al. (2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation.". Nat. Genet. 34 (3): 330–6. doi:10.1038/ng1182. PMID 12819782. 
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
  • Sampath P, Mazumder B, Seshadri V, et al. (2004). "Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation.". Cell 119 (2): 195–208. doi:10.1016/j.cell.2004.09.030. PMID 15479637. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
 This article on a gene on chromosome 7 is a stub. You can help Wikipedia by expanding it.