Muconolactone Delta-isomerase

From Wikipedia, the free encyclopedia

In enzymology, a muconolactone Delta-isomerase (EC 5.3.3.4) is an enzyme that catalyzes the chemical reaction

(S)-5-oxo-2,5-dihydrofuran-2-acetate $\rightleftharpoons$ 5-oxo-4,5-dihydrofuran-2-acetate

Hence, this enzyme has one substrate, (S)-5-oxo-2,5-dihydrofuran-2-acetate, and one product, 5-oxo-4,5-dihydrofuran-2-acetate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is 5-oxo-4,5-dihydrofuran-2-acetate Delta3-Delta2-isomerase. This enzyme is also called muconolactone isomerase. This enzyme participates in benzoate degradation via hydroxylation.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1MLI.

[edit] References

IUBMB entry for 5.3.3.4
BRENDA references for 5.3.3.4 (Recommended.)
PubMed references for 5.3.3.4
PubMed Central references for 5.3.3.4
Google Scholar references for 5.3.3.4
Ornston LN (1966). "The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. 3. Enzymes of the catechol pathway". J. Biol. Chem. 241: 3795–9. PMID 5330966.
Ornston LN (1970). "Conversion of catechol and protocatechuate to beta-ketoadipate (Pseudomonas putida)". Methods Enzymol. 17A: 529–549.