MUC5B

From Wikipedia, the free encyclopedia

Mucin 5B, oligomeric mucus/gel-forming

Identifiers

MUC5B; MUC5; MUC9; MG1

External IDs

Gene ontology
Molecular Function:	• extracellular matrix structural constituent • protein binding
Cellular Component:	• extracellular region
Biological Process:	• cell adhesion • biological_process

Orthologs

Human

Mouse

Entrez

727897

n/a

Refseq

XM_001126093 (mRNA)
XP_001126093 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

Mucin 5B, oligomeric mucus/gel-forming, also known as MUC5B, is a human gene.^[1]

[edit] References

^ Entrez Gene: MUC5B mucin 5B, oligomeric mucus/gel-forming.

[edit] Further reading

Zalewska A, Zwierz K, Zółkowski K, Gindzieński A (2002). "Structure and biosynthesis of human salivary mucins.". Acta Biochim. Pol. 47 (4): 1067–79. PMID 11996097.
Douglas WH, Reeh ES, Ramasubbu N, et al. (1991). "Statherin: a major boundary lubricant of human saliva.". Biochem. Biophys. Res. Commun. 180 (1): 91–7. PMID 1718282.
Meezaman D, Charles P, Daskal E, et al. (1994). "Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5).". J. Biol. Chem. 269 (17): 12932–9. PMID 7513696.
Dufosse J, Porchet N, Audie JP, et al. (1993). "Degenerate 87-base-pair tandem repeats create hydrophilic/hydrophobic alternating domains in human mucin peptides mapped to 11p15.". Biochem. J. 293 ( Pt 2): 329–37. PMID 7916618.
Troxler RF, Offner GD, Zhang F, et al. (1996). "Molecular cloning of a novel high molecular weight mucin (MG1) from human sublingual gland.". Biochem. Biophys. Res. Commun. 217 (3): 1112–9. doi:10.1006/bbrc.1995.2884. PMID 8554565.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Desseyn JL, Guyonnet-Dupérat V, Porchet N, et al. (1997). "Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family.". J. Biol. Chem. 272 (6): 3168–78. PMID 9013550.
Nielsen PA, Bennett EP, Wandall HH, et al. (1997). "Identification of a major human high molecular weight salivary mucin (MG1) as tracheobronchial mucin MUC5B.". Glycobiology 7 (3): 413–9. PMID 9147051.
Keates AC, Nunes DP, Afdhal NH, et al. (1997). "Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B.". Biochem. J. 324 ( Pt 1): 295–303. PMID 9164870.
Desseyn JL, Aubert JP, Van Seuningen I, et al. (1997). "Genomic organization of the 3' region of the human mucin gene MUC5B.". J. Biol. Chem. 272 (27): 16873–83. PMID 9201995.
Offner GD, Nunes DP, Keates AC, et al. (1998). "The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions.". Biochem. Biophys. Res. Commun. 251 (1): 350–5. doi:10.1006/bbrc.1998.9469. PMID 9790959.
Desseyn JL, Buisine MP, Porchet N, et al. (1998). "Genomic organization of the human mucin gene MUC5B. cDNA and genomic sequences upstream of the large central exon.". J. Biol. Chem. 273 (46): 30157–64. PMID 9804771.
Desseyn JL, Rousseau K, Laine A (1999). "Fifty-nine bp repeat polymorphism in the uncommon intron 36 of the human mucin gene MUC5B.". Electrophoresis 20 (3): 493–6. doi:10.1002/(SICI)1522-2683(19990301)20:3<493::AID-ELPS493>3.0.CO;2-7. PMID 10217161.
Iontcheva I, Oppenheim FG, Offner GD, Troxler RF (2000). "Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system.". J. Dent. Res. 79 (2): 732–9. PMID 10728974.
Chen Y, Zhao YH, Di YP, Wu R (2002). "Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region.". Am. J. Respir. Cell Mol. Biol. 25 (5): 542–53. PMID 11713095.
Thomsson KA, Prakobphol A, Leffler H, et al. (2002). "The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse.". Glycobiology 12 (1): 1–14. PMID 11825880.
Raynal BD, Hardingham TE, Thornton DJ, Sheehan JK (2002). "Concentrated solutions of salivary MUC5B mucin do not replicate the gel-forming properties of saliva.". Biochem. J. 362 (Pt 2): 289–96. PMID 11853536.
Banderas-Tarabay JA, Zacarías-D'Oleire IG, Garduño-Estrada R, et al. (2003). "Electrophoretic analysis of whole saliva and prevalence of dental caries. A study in Mexican dental students.". Arch. Med. Res. 33 (5): 499–505. PMID 12459324.
Raynal BD, Hardingham TE, Sheehan JK, Thornton DJ (2003). "Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus.". J. Biol. Chem. 278 (31): 28703–10. doi:10.1074/jbc.M304632200. PMID 12756239.