MTUS1

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Mitochondrial tumor suppressor 1
Identifiers
Symbol(s) MTUS1; ATIP; DKFZp586D1519; DKFZp686F20243; FLJ14295; KIAA1288; MP44; MTSG1
External IDs OMIM: 609589 MGI: 2142572 HomoloGene: 18725
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 57509 102103
Ensembl ENSG00000129422 ENSMUSG00000045636
Refseq NM_001001924 (mRNA)
NP_001001924 (protein)		 NM_178902 (mRNA)
NP_849233 (protein)
Location Chr 8: 17.55 - 17.7 Mb Chr 8: 42.49 - 42.61 Mb
Pubmed search [1] [2]

Mitochondrial tumor suppressor 1, also known as MTUS1, is a human gene.[1]

This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.[1]

[edit] References

  1. ^ a b Entrez Gene: MTUS1 mitochondrial tumor suppressor 1.

[edit] Further reading

  • Di Benedetto M, Pineau P, Nouet S, et al. (2006). "Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma.". Mol. Cell. Endocrinol. 252 (1-2): 207-15. doi:10.1016/j.mce.2006.03.014. PMID 16650523. 
  • Frank B, Bermejo JL, Hemminki K, et al. (2007). "Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk.". Carcinogenesis 28 (7): 1442-5. doi:10.1093/carcin/bgm033. PMID 17301065. 
  • Di Benedetto M, Bièche I, Deshayes F, et al. (2006). "Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP.". Gene 380 (2): 127-36. doi:10.1016/j.gene.2006.05.021. PMID 16887298. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Nouet S, Amzallag N, Li JM, et al. (2004). "Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP.". J. Biol. Chem. 279 (28): 28989-97. doi:10.1074/jbc.M403880200. PMID 15123706. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Seibold S, Rudroff C, Weber M, et al. (2003). "Identification of a new tumor suppressor gene located at chromosome 8p21.3-22.". FASEB J. 17 (9): 1180-2. doi:10.1096/fj.02-0934fje. PMID 12692079. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337-45. PMID 10574462. 
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