MTSS1

From Wikipedia, the free encyclopedia

Metastasis suppressor 1

PDB rendering based on 2d1k.

Available structures: 2d1k, 2d1l

Identifiers

Symbol(s)

MTSS1; FLJ44694; KIAA0429; MIM; MIMA; MIMB

External IDs

OMIM: 608486 MGI: 2384818 HomoloGene: 8841

Gene ontology
Molecular Function:	• actin monomer binding • receptor binding
Cellular Component:	• ruffle • cytoplasm • actin cytoskeleton • endocytic vesicle
Biological Process:	• cell motility • actin filament organization • cell cycle • cell adhesion • transmembrane receptor protein tyrosine kinase signaling pathway • nervous system development • muscle development • microspike biogenesis • actin filament polymerization • negative regulation of progression through cell cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014751 (mRNA)
NP_055566 (protein)

NM_144800 (mRNA)
NP_659049 (protein)

Location

Chr 8: 125.63 - 125.81 Mb

Chr 15: 58.77 - 58.91 Mb

Pubmed search

[1]

[2]

Metastasis suppressor 1, also known as MTSS1, is a human gene.^[1] True to its name, it codes for a metastasis suppressor.

[edit] References

^ Entrez Gene: MTSS1 metastasis suppressor 1.

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307–13. PMID 9455477.
Lee YG, Macoska JA, Korenchuk S, Pienta KJ (2003). "MIM, a potential metastasis suppressor gene in bladder cancer.". Neoplasia 4 (4): 291–4. doi:10.1038/sj.neo.7900231. PMID 12082544.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mattila PK, Salminen M, Yamashiro T, Lappalainen P (2003). "Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain.". J. Biol. Chem. 278 (10): 8452–9. doi:10.1074/jbc.M212113200. PMID 12482861.
Woodings JA, Sharp SJ, Machesky LM (2003). "MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta.". Biochem. J. 371 (Pt 2): 463–71. doi:10.1042/BJ20021962. PMID 12570871.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Yamagishi A, Masuda M, Ohki T, et al. (2004). "A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein.". J. Biol. Chem. 279 (15): 14929–36. doi:10.1074/jbc.M309408200. PMID 14752106.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Nixdorf S, Grimm MO, Loberg R, et al. (2004). "Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines.". Cancer Lett. 215 (2): 209–20. doi:10.1016/j.canlet.2004.05.002. PMID 15488640.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Callahan CA, Ofstad T, Horng L, et al. (2004). "MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription.". Genes Dev. 18 (22): 2724–9. doi:10.1101/gad.1221804. PMID 15545630.
Gonzalez-Quevedo R, Shoffer M, Horng L, Oro AE (2005). "Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4.". J. Cell Biol. 168 (3): 453–63. doi:10.1083/jcb.200409078. PMID 15684034.
Bompard G, Sharp SJ, Freiss G, Machesky LM (2006). "Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B.". J. Cell. Sci. 118 (Pt 22): 5393–403. doi:10.1242/jcs.02640. PMID 16280553.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Utikal J, Gratchev A, Muller-Molinet I, et al. (2006). "The expression of metastasis suppressor MIM/MTSS1 is regulated by DNA methylation.". Int. J. Cancer 119 (10): 2287–93. doi:10.1002/ijc.22106. PMID 16921485.
Ma S, Guan XY, Lee TK, Chan KW (2007). "Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma.". Hum. Pathol. 38 (8): 1201–6. doi:10.1016/j.humpath.2007.01.004. PMID 17442377.