MTPN

From Wikipedia, the free encyclopedia

Myotrophin

PDB rendering based on 1myo.

Available structures: 1myo, 2myo

Identifiers

Symbol(s)

MTPN; FLJ31098; GCDP; V-1

External IDs

OMIM: 606484 MGI: 99445 HomoloGene: 40607

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• cellular_component • intracellular
Biological Process:	• regulation of translation • cell growth • regulation of striated muscle development • neuron differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_145808 (mRNA)
NP_665807 (protein)

NM_008098 (mRNA)
NP_032124 (protein)

Location

Chr 7: 135.26 - 135.31 Mb

Chr 6: 35.44 - 35.47 Mb

Pubmed search

[1]

[2]

Myotrophin, also known as MTPN, is a human gene.^[1]

[edit] References

^ Entrez Gene: MTPN myotrophin.

[edit] Further reading

Taoka M, Yamakuni T, Song SY, et al. (1992). "A rat cerebellar protein containing the cdc10/SWI6 motif.". Eur. J. Biochem. 207 (2): 615–20. PMID 1633812.
Sil P, Misono K, Sen S (1993). "Myotrophin in human cardiomyopathic heart.". Circ. Res. 73 (1): 98–108. PMID 8508536.
Sivasubramanian N, Adhikary G, Sil PC, Sen S (1996). "Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitro.". J. Biol. Chem. 271 (5): 2812–6. PMID 8576259.
Anderson KM, Berrebi-Bertrand I, Kirkpatrick RB, et al. (1999). "cDNA sequence and characterization of the gene that encodes human myotrophin/V-1 protein, a mediator of cardiac hypertrophy.". J. Mol. Cell. Cardiol. 31 (4): 705–19. doi:10.1006/jmcc.1998.0903. PMID 10329199.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Mitra S, Timur AA, Gupta S, et al. (2001). "Assignment of myotrophin to human chromosome band 7q33-->q35 by in situ hybridization.". Cytogenet. Cell Genet. 93 (1-2): 151–2. PMID 11474205.
Knuefermann P, Chen P, Misra A, et al. (2002). "Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers.". J. Biol. Chem. 277 (26): 23888–97. doi:10.1074/jbc.M202937200. PMID 11971907.
Gupta S, Sen S (2002). "Myotrophin-kappaB DNA interaction in the initiation process of cardiac hypertrophy.". Biochim. Biophys. Acta 1589 (3): 247–60. PMID 12031792.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Xiong Z, Liu E, Yan Y, et al. (2006). "An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions.". J. Immunol. 177 (7): 4907–16. PMID 16982933.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.