MTMR3

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Myotubularin related protein 3
Identifiers
Symbol(s)	MTMR3; FYVE-DSP1; KIAA0371; ZFYVE10
External IDs	OMIM: 603558 MGI: 1921552 HomoloGene: 23662
Gene ontology Molecular Function: • inositol or phosphatidylinositol phosphatase activity • protein serine/threonine phosphatase activity • protein tyrosine phosphatase activity • zinc ion binding • hydrolase activity • metal ion binding Cellular Component: • membrane fraction • cytoplasm Biological Process: • protein amino acid dephosphorylation • phospholipid dephosphorylation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	8897	74302
Ensembl	ENSG00000100330	ENSMUSG00000034354
Uniprot	Q13615	Q5NCA1
Refseq	NM_021090 (mRNA) NP_066576 (protein)	NM_028860 (mRNA) NP_083136 (protein)
Location	Chr 22: 28.61 - 28.75 Mb	Chr 11: 4.38 - 4.43 Mb
Pubmed search	[1]	[2]

Myotubularin related protein 3, also known as MTMR3, is a human gene.^[1]

This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.^[1]

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