MTF1
From Wikipedia, the free encyclopedia
Metal-regulatory transcription factor 1
|
||||||||||||||
Identifiers | ||||||||||||||
Symbol(s) | MTF1; MGC23036; MTF-1; ZRF | |||||||||||||
External IDs | OMIM: 600172 MGI: 101786 HomoloGene: 4347 | |||||||||||||
|
||||||||||||||
RNA expression pattern | ||||||||||||||
Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 4520 | 17764 | ||||||||||||
Ensembl | ENSG00000188786 | ENSMUSG00000028890 | ||||||||||||
Uniprot | Q14872 | Q80W60 | ||||||||||||
Refseq | NM_005955 (mRNA) NP_005946 (protein) |
XM_622562 (mRNA) XP_622562 (protein) |
||||||||||||
Location | Chr 1: 38.05 - 38.1 Mb | Chr 4: 124.3 - 124.35 Mb | ||||||||||||
Pubmed search | [1] | [2] |
Metal-regulatory transcription factor 1, also known as MTF1, is a human gene.[1]
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).[1]
[edit] References
[edit] Further reading
- Westin G, Schaffner W (1989). "A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene.". EMBO J. 7 (12): 3763-70. PMID 3208749.
- Brugnera E, Georgiev O, Radtke F, et al. (1994). "Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1.". Nucleic Acids Res. 22 (15): 3167-73. PMID 8065932.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
- Chen X, Chu M, Giedroc DP (1999). "MRE-Binding transcription factor-1: weak zinc-binding finger domains 5 and 6 modulate the structure, affinity, and specificity of the metal-response element complex.". Biochemistry 38 (39): 12915-25. PMID 10504263.
- Otsuka F, Okugaito I, Ohsawa M, et al. (2000). "Novel responses of ZRF, a variant of human MTF-1, to in vivo treatment with heavy metals.". Biochim. Biophys. Acta 1492 (2-3): 330-40. PMID 11004505.
- Saydam N, Georgiev O, Nakano MY, et al. (2001). "Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals.". J. Biol. Chem. 276 (27): 25487-95. doi: . PMID 11306562.
- Saydam N, Adams TK, Steiner F, et al. (2002). "Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription.". J. Biol. Chem. 277 (23): 20438-45. doi: . PMID 11923282.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi: . PMID 12477932.
- Majumder S, Ghoshal K, Summers D, et al. (2003). "Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1.". J. Biol. Chem. 278 (28): 26216-26. doi: . PMID 12716893.
- Saydam N, Steiner F, Georgiev O, Schaffner W (2003). "Heat and heavy metal stress synergize to mediate transcriptional hyperactivation by metal-responsive transcription factor MTF-1.". J. Biol. Chem. 278 (34): 31879-83. doi: . PMID 12805380.
- Chen X, Zhang B, Harmon PM, et al. (2004). "A novel cysteine cluster in human metal-responsive transcription factor 1 is required for heavy metal-induced transcriptional activation in vivo.". J. Biol. Chem. 279 (6): 4515-22. doi: . PMID 14610091.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi: . PMID 14702039.
- Balamurugan K, Egli D, Selvaraj A, et al. (2005). "Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison.". Biol. Chem. 385 (7): 597-603. PMID 15318808.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi: . PMID 15489334.
- Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S (2005). "Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors.". Oncogene 24 (13): 2204-17. doi: . PMID 15735762.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi: . PMID 16189514.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi: . PMID 16710414.
[edit] External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
|