MTERF

From Wikipedia, the free encyclopedia

Mitochondrial transcription termination factor

Identifiers

MTERF; MGC131634

External IDs

OMIM: 602318 MGI: 1918240 HomoloGene: 5073

Gene ontology
Molecular Function:	• DNA binding • double-stranded DNA binding • transcription termination factor activity
Cellular Component:	• mitochondrion
Biological Process:	• transcription • regulation of transcription, DNA-dependent • RNA transcription termination from mitochondrial promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006980 (mRNA)
NP_008911 (protein)

NM_001042670 (mRNA)
NP_001036135 (protein)

Location

Chr 7: 91.34 - 91.35 Mb

Chr 5: 4.2 - 4.2 Mb

Pubmed search

[1]

[2]

Mitochondrial transcription termination factor, also known as MTERF, is a human gene.^[1]

This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding.^[1]

[edit] References

^ ^a ^b Entrez Gene: MTERF mitochondrial transcription termination factor.

[edit] Further reading

Daga A, Micol V, Hess D, et al. (1993). "Molecular characterization of the transcription termination factor from human mitochondria.". J. Biol. Chem. 268 (11): 8123-30. PMID 7681833.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Fernandez-Silva P, Martinez-Azorin F, Micol V, Attardi G (1997). "The human mitochondrial transcription termination factor (mTERF) is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions.". EMBO J. 16 (5): 1066-79. doi:10.1093/emboj/16.5.1066. PMID 9118945.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097-108. PMID 9847074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767-72. doi:10.1126/science.1083423. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948.
Asin-Cayuela J, Helm M, Attardi G (2004). "A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity.". J. Biol. Chem. 279 (15): 15670-7. doi:10.1074/jbc.M312537200. PMID 14744862.
Prieto-Martín A, Montoya J, Martínez-Azorín F (2004). "Phosphorylation of rat mitochondrial transcription termination factor (mTERF) is required for transcription termination but not for binding to DNA.". Nucleic Acids Res. 32 (7): 2059-68. doi:10.1093/nar/gkh528. PMID 15087485.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Asin-Cayuela J, Schwend T, Farge G, Gustafsson CM (2005). "The human mitochondrial transcription termination factor (mTERF) is fully active in vitro in the non-phosphorylated form.". J. Biol. Chem. 280 (27): 25499-505. doi:10.1074/jbc.M501145200. PMID 15899902.
Hyvärinen AK, Pohjoismäki JL, Reyes A, et al. (2007). "The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA.". Nucleic Acids Res. 35 (19): 6458-74. doi:10.1093/nar/gkm676. PMID 17884915.