MTCP1

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Mature T-cell proliferation 1
PDB rendering based on 1a1x.
Available structures: 1a1x, 1hp8, 1qtt, 1qtu, 2hp8
Identifiers
Symbol(s) MTCP1; C6.1B
External IDs OMIM: 300116 MGI: 102699 HomoloGene: 82921
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4515 17763
Ensembl ENSG00000182712 ENSMUSG00000031200
Uniprot P56278 Q60945
Refseq NM_001018024 (mRNA)
NP_001018024 (protein)		 NM_001039373 (mRNA)
NP_001034462 (protein)
Location Chr X: 153.94 - 154.03 Mb Chr X: 71.66 - 71.67 Mb
Pubmed search [1] [2]

Mature T-cell proliferation 1, also known as MTCP1, is a human gene.[1]

This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. The gene has two ORFs that encode two different proteins. The upstream ORF encodes a 13kDa protein that is a member of the TCL1 family; this protein may be involved in leukemogenesis. The downstream ORF encodes an 8kDa protein that localizes to mitochondria. Alternative splicing results in multiple transcript variants.[1]

[edit] References

  1. ^ a b Entrez Gene: MTCP1 mature T-cell proliferation 1.

[edit] Further reading

  • Kenwrick S, Levinson B, Taylor S, et al. (1993). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene.". Hum. Mol. Genet. 1 (3): 179-86. PMID 1303175. 
  • Madani A, Soulier J, Schmid M, et al. (1995). "The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein.". Oncogene 10 (11): 2259-62. PMID 7784073. 
  • Soulier J, Madani A, Cacheux V, et al. (1994). "The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation.". Oncogene 9 (12): 3565-70. PMID 7970717. 
  • Thick J, Mak YF, Metcalfe J, et al. (1994). "A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia.". Leukemia 8 (4): 564-73. PMID 8152252. 
  • Fisch P, Forster A, Sherrington PD, et al. (1993). "The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another.". Oncogene 8 (12): 3271-6. PMID 8247530. 
  • Stern MH, Soulier J, Rosenzwajg M, et al. (1993). "MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations.". Oncogene 8 (9): 2475-83. PMID 8361760. 
  • Madani A, Choukroun V, Soulier J, et al. (1996). "Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations.". Blood 87 (5): 1923-7. PMID 8634440. 
  • Gritti C, Choukroun V, Soulier J, et al. (1997). "Alternative origin of p13MTCP1-encoding transcripts in mature T-cell proliferations with t(X;14) translocations.". Oncogene 15 (11): 1329-35. doi:10.1038/sj.onc.1201303. PMID 9315101. 
  • Barthe P, Yang YS, Chiche L, et al. (1998). "Solution structure of human p8MTCP1, a cysteine-rich protein encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly motif.". J. Mol. Biol. 274 (5): 801-15. doi:10.1006/jmbi.1997.1438. PMID 9405159. 
  • Du Bois GC, Song SP, Kulikovskaya I, et al. (1998). "Purification and characterization of recombinant forms of TCL-1 and MTCP-1 proteins.". Protein Expr. Purif. 12 (2): 215-25. doi:10.1006/prep.1997.0822. PMID 9518463. 
  • Fu ZQ, Du Bois GC, Song SP, et al. (1998). "Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies.". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3413-8. PMID 9520380. 
  • Yang YS, Guignard L, Padilla A, et al. (1998). "Solution structure of the recombinant human oncoprotein p13MTCP1.". J. Biomol. NMR 11 (3): 337-54. PMID 9691281. 
  • Guignard L, Padilla A, Mispelter J, et al. (2000). "Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data.". J. Biomol. NMR 17 (3): 215-30. PMID 10959629. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863. 
  • Laine J, Künstle G, Obata T, Noguchi M (2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family.". J. Biol. Chem. 277 (5): 3743-51. doi:10.1074/jbc.M107069200. PMID 11707444. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901. 
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