MT3

From Wikipedia, the free encyclopedia

Metallothionein 3

PDB rendering based on 2f5h.

Available structures: 2f5h, 2fj4, 2fj5

Identifiers

Symbol(s)

MT3; GIF; GIFB; GRIF

External IDs

OMIM: 139255 MGI: 97173 HomoloGene: 4346

Gene ontology
Molecular Function:	• iron ion binding • copper ion binding • zinc ion binding • electron carrier activity • antioxidant activity • metal ion binding
Cellular Component:	• synaptic vesicle
Biological Process:	• response to hypoxia • electron transport • cellular metal ion homeostasis • cell proliferation • removal of superoxide radicals • negative regulation of cell growth • negative regulation of dendrite morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005954 (mRNA)
NP_005945 (protein)

NM_013603 (mRNA)
NP_038631 (protein)

Location

Chr 16: 55.18 - 55.18 Mb

Chr 8: 97.04 - 97.04 Mb

Pubmed search

[1]

[2]

Metallothionein 3, also known as MT3, is a human gene.^[1]

[edit] References

^ Entrez Gene: MT3 metallothionein 3.

[edit] Further reading

Aschner M (1996). "The functional significance of brain metallothioneins.". FASEB J. 10 (10): 1129–36. PMID 8751715.
Tsuji S, Kobayashi H, Uchida Y, et al. (1993). "Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease.". EMBO J. 11 (13): 4843–50. PMID 1464312.
Palmiter RD, Findley SD, Whitmore TE, Durnam DM (1992). "MT-III, a brain-specific member of the metallothionein gene family.". Proc. Natl. Acad. Sci. U.S.A. 89 (14): 6333–7. PMID 1631128.
Uchida Y, Takio K, Titani K, et al. (1991). "The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein.". Neuron 7 (2): 337–47. PMID 1873033.
Hewitt JE, Gordon MM, Taggart RT, et al. (1991). "Human gastric intrinsic factor: characterization of cDNA and genomic clones and localization to human chromosome 11.". Genomics 10 (2): 432–40. PMID 2071148.
Amoureux MC, Wurch T, Pauwels PJ (1995). "Modulation of metallothionein-III mRNA content and growth rate of rat C6-glial cells by transfection with human 5-HT1D receptor genes.". Biochem. Biophys. Res. Commun. 214 (2): 639–45. doi:10.1006/bbrc.1995.2334. PMID 7677777.
Naruse S, Igarashi S, Furuya T, et al. (1994). "Structures of the human and mouse growth inhibitory factor-encoding genes.". Gene 144 (2): 283–7. PMID 8039715.
Moffatt P, Séguin C (1998). "Expression of the gene encoding metallothionein-3 in organs of the reproductive system.". DNA Cell Biol. 17 (6): 501–10. PMID 9655243.
Garrett SH, Sens MA, Shukla D, et al. (1999). "Metallothionein isoform 3 expression in the human prostate and cancer-derived cell lines.". Prostate 41 (3): 196–202. PMID 10517878.
Ye B, Maret W, Vallee BL (2001). "Zinc metallothionein imported into liver mitochondria modulates respiration.". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2317–22. doi:10.1073/pnas.041619198. PMID 11226237.
Kim D, Garrett SH, Sens MA, et al. (2002). "Metallothionein isoform 3 and proximal tubule vectorial active transport.". Kidney Int. 61 (2): 464–72. doi:10.1046/j.1523-1755.2002.00153.x. PMID 11849386.
Palumaa P, Eriste E, Njunkova O, et al. (2002). "Brain-specific metallothionein-3 has higher metal-binding capacity than ubiquitous metallothioneins and binds metals noncooperatively.". Biochemistry 41 (19): 6158–63. PMID 11994011.
Uchida Y, Gomi F, Masumizu T, Miura Y (2002). "Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging.". J. Biol. Chem. 277 (35): 32353–9. doi:10.1074/jbc.M111263200. PMID 12058024.
You HJ, Lee KJ, Jeong HG (2002). "Overexpression of human metallothionein-III prevents hydrogen peroxide-induced oxidative stress in human fibroblasts.". FEBS Lett. 521 (1-3): 175–9. PMID 12067712.
Roschitzki B, Vasák M (2002). "A distinct Cu(4)-thiolate cluster of human metallothionein-3 is located in the N-terminal domain.". J. Biol. Inorg. Chem. 7 (6): 611–6. doi:10.1007/s00775-002-0339-1. PMID 12072966.
Dutta R, Sens DA, Somji S, et al. (2002). "Metallothionein isoform 3 expression inhibits cell growth and increases drug resistance of PC-3 prostate cancer cells.". Prostate 52 (2): 89–97. doi:10.1002/pros.10097. PMID 12111700.
Tate DJ, Miceli MV, Newsome DA (2002). "Expression of metallothionein isoforms in human chorioretinal complex.". Curr. Eye Res. 24 (1): 12–25. PMID 12187490.
You HJ, Oh DH, Choi CY, et al. (2002). "Protective effect of metallothionein-III on DNA damage in response to reactive oxygen species.". Biochim. Biophys. Acta 1573 (1): 33–8. PMID 12383939.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.