MT1X

From Wikipedia, the free encyclopedia

Metallothionein 1X

PDB rendering based on 1mhu.

Available structures: 1mhu, 1mrb, 1mrt

Identifiers

Symbol(s)

MT1X; MT1; MT-1l

External IDs

OMIM: 156359 HomoloGene: 88734

Gene ontology
Molecular Function:	• copper ion binding • zinc ion binding • cadmium ion binding • metal ion binding
Biological Process:	• cellular zinc ion homeostasis • nitric oxide mediated signal transduction • response to metal ion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_005952 (mRNA)
NP_005943 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 16: 55.27 - 55.28 Mb

n/a

Pubmed search

[1]

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Metallothionein 1X, also known as MT1X, is a human gene.^[1]

[edit] References

^ Entrez Gene: MT1X metallothionein 1X.

[edit] Further reading

West AK, Stallings R, Hildebrand CE, et al. (1991). "Human metallothionein genes: structure of the functional locus at 16q13.". Genomics 8 (3): 513-8. PMID 2286373.
Stennard FA, Holloway AF, Hamilton J, West AK (1994). "Characterisation of six additional human metallothionein genes.". Biochim. Biophys. Acta 1218 (3): 357-65. PMID 8049263.
Pauwels M, van Weyenbergh J, Soumillion A, et al. (1994). "Induction by zinc of specific metallothionein isoforms in human monocytes.". Eur. J. Biochem. 220 (1): 105-10. PMID 8119276.
Mididoddi S, McGuirt JP, Sens MA, et al. (1996). "Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney.". Toxicol. Lett. 85 (1): 17-27. PMID 8619255.
Holloway AF, Stennard FA, West AK (1997). "Human metallothionein gene MT1L mRNA is present in several human tissues but is unlikely to produce a metallothionein protein.". FEBS Lett. 404 (1): 41-4. PMID 9074634.
Garrett SH, Somji S, Todd JH, et al. (1999). "Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals.". Environ. Health Perspect. 106 (12): 825-32. PMID 9831543.
Hellemans G, Soumillion A, Proost P, et al. (2000). "Metallothioneins in human kidneys and associated tumors.". Nephron 83 (4): 331-40. PMID 10575295.
Garrett SH, Sens MA, Shukla D, et al. (2000). "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer.". Prostate 43 (2): 125-35. PMID 10754528.
Vandeghinste N, Proost P, De Ley M (2000). "Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes.". Cell. Mol. Biol. (Noisy-le-grand) 46 (2): 419-33. PMID 10774930.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Rahman MT, De Ley M (2001). "Metallothionein isogene transcription in red blood cell precursors from human cord blood.". Eur. J. Biochem. 268 (3): 849-56. PMID 11168427.
Garrett SH, Belcastro M, Sens MA, et al. (2001). "Acute exposure to arsenite induces metallothionein isoform-specific gene expression in human proximal tubule cells.". J. Toxicol. Environ. Health Part A 64 (4): 343-55. PMID 11693492.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.". Nat. Med. 9 (2): 191-7. doi:10.1038/nm822. PMID 12539042.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311-26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.