MSH5

From Wikipedia, the free encyclopedia

MutS homolog 5 (E. coli)

Identifiers

MSH5; DKFZp434C1615; G7; MGC2939; MutSH5; NG23

External IDs

OMIM: 603382 MGI: 1329021 HomoloGene: 8415

Gene ontology
Molecular Function:	• nucleotide binding • damaged DNA binding • ATP binding
Biological Process:	• DNA metabolic process • mismatch repair • meiosis • meiotic recombination • meiotic prophase II

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001131770 (mRNA)
XP_001131770 (protein)

NM_013600 (mRNA)
NP_038628 (protein)

Location

Chr c6_COX: 31.84 - 31.87 Mb

Chr 17: 34.64 - 34.65 Mb

Pubmed search

[1]

[2]

MutS homolog 5 (E. coli), also known as MSH5, is a human gene.^[1]

This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair or meiotic recombination processes. This protein is similar to a Saccharomyces cerevisiae protein that participates in meiotic segregation fidelity and crossing-over. This protein forms heterooligomers with another member of this family, mutS homolog 4. Alternative splicing results in four transcript variants encoding three different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: MSH5 mutS homolog 5 (E. coli).

[edit] Further reading

Her C, Zhao N, Wu X, Tompkins JD (2007). "MutS homologues hMSH4 and hMSH5: diverse functional implications in humans.". Front. Biosci. 12: 905-11. PMID 17127347.
Sargent CA, Dunham I, Campbell RD (1989). "Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region.". EMBO J. 8 (8): 2305-12. PMID 2477242.
Albertella MR, Jones H, Thomson W, et al. (1997). "Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B).". Genomics 36 (2): 240-51. doi:10.1006/geno.1996.0459. PMID 8812450.
Her C, Doggett NA (1999). "Cloning, structural characterization, and chromosomal localization of the human orthologue of Saccharomyces cerevisiae MSH5 gene.". Genomics 52 (1): 50-61. doi:10.1006/geno.1998.5374. PMID 9740671.
Winand NJ, Panzer JA, Kolodner RD (1998). "Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene.". Genomics 53 (1): 69-80. doi:10.1006/geno.1998.5447. PMID 9787078.
Edelmann W, Cohen PE, Kneitz B, et al. (1999). "Mammalian MutS homologue 5 is required for chromosome pairing in meiosis.". Nat. Genet. 21 (1): 123-7. doi:10.1038/5075. PMID 9916805.
Bocker T, Barusevicius A, Snowden T, et al. (1999). "hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis.". Cancer Res. 59 (4): 816-22. PMID 10029069.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.". Genome Res. 13 (12): 2621-36. doi:10.1101/gr.1736803. PMID 14656967.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311-26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Snowden T, Acharya S, Butz C, et al. (2004). "hMSH4-hMSH5 recognizes Holliday Junctions and forms a meiosis-specific sliding clamp that embraces homologous chromosomes.". Mol. Cell 15 (3): 437-51. doi:10.1016/j.molcel.2004.06.040. PMID 15304223.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Yi W, Wu X, Lee TH, et al. (2005). "Two variants of MutS homolog hMSH5: prevalence in humans and effects on protein interaction.". Biochem. Biophys. Res. Commun. 332 (2): 524-32. doi:10.1016/j.bbrc.2005.04.154. PMID 15907804.
Lee TH, Yi W, Griswold MD, et al. (2006). "Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment.". DNA Repair (Amst.) 5 (1): 32-42. doi:10.1016/j.dnarep.2005.07.004. PMID 16122992.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Sekine H, Ferreira RC, Pan-Hammarström Q, et al. (2007). "Role for Msh5 in the regulation of Ig class switch recombination.". Proc. Natl. Acad. Sci. U.S.A. 104 (17): 7193-8. doi:10.1073/pnas.0700815104. PMID 17409188.
Szafranski K, Schindler S, Taudien S, et al.. "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns." 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMID 17672918.