MS4A7

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Membrane-spanning 4-domains, subfamily A, member 7
Identifiers
Symbol(s) MS4A7; 4SPAN2; CD20L4; CFFM4; MGC22368; MS4A8
External IDs OMIM: 606502 MGI: 1918846 HomoloGene: 10922
Orthologs
Human Mouse
Entrez 58475 109225
Ensembl ENSG00000166927 ENSMUSG00000024672
Uniprot Q9GZW8 n/a
Refseq NM_021201 (mRNA)
NP_067024 (protein)		 NM_001025610 (mRNA)
NP_001020781 (protein)
Location Chr 11: 59.9 - 59.92 Mb Chr 19: 11.39 - 11.4 Mb
Pubmed search [1] [2]

Membrane-spanning 4-domains, subfamily A, member 7, also known as MS4A7, is a human gene.[1]

This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed.[1]

[edit] References

  1. ^ a b Entrez Gene: MS4A7 membrane-spanning 4-domains, subfamily A, member 7.

[edit] Further reading

  • Ishibashi K, Suzuki M, Sasaki S, Imai M (2001). "Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor.". Gene 264 (1): 87–93. PMID 11245982. 
  • Liang Y, Tedder TF (2001). "Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse.". Genomics 72 (2): 119–27. doi:10.1006/geno.2000.6472. PMID 11401424. 
  • Liang Y, Buckley TR, Tu L, et al. (2001). "Structural organization of the human MS4A gene cluster on Chromosome 11q12.". Immunogenetics 53 (5): 357–68. PMID 11486273. 
  • Gingras MC, Lapillonne H, Margolin JF (2001). "CFFM4: a new member of the CD20/FcepsilonRIbeta family.". Immunogenetics 53 (6): 468–76. doi:10.1007/s002510100345. PMID 11685457. 
  • Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMID 11752456. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743. 
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