MS4A3

From Wikipedia, the free encyclopedia

Membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)

Identifiers

MS4A3; CD20L; HTM4

External IDs

OMIM: 606498 MGI: 2158468 HomoloGene: 4472

Gene ontology
Molecular Function:	• receptor activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001031666 (mRNA)
NP_001026836 (protein)

NM_133246 (mRNA)
NP_573509 (protein)

Location

Chr 11: 59.58 - 59.6 Mb

Chr 19: 11.7 - 11.71 Mb

Pubmed search

[1]

[2]

Membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific), also known as MS4A3, is a human gene.^[1]

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described.^[1]

[edit] References

^ ^a ^b Entrez Gene: MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific).

[edit] Further reading

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Chinami M, Yano Y, Yang X, et al. (2005). "Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2.". J. Biol. Chem. 280 (17): 17235-42. doi:10.1074/jbc.M413437200. PMID 15671017.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Donato JL, Ko J, Kutok JL, et al. (2002). "Human HTm4 is a hematopoietic cell cycle regulator.". J. Clin. Invest. 109 (1): 51-8. doi:10.1172/JCI14025. PMID 11781350.
Liang Y, Buckley TR, Tu L, et al. (2001). "Structural organization of the human MS4A gene cluster on Chromosome 11q12.". Immunogenetics 53 (5): 357-68. PMID 11486273.
Liang Y, Tedder TF (2001). "Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse.". Genomics 72 (2): 119-27. doi:10.1006/geno.2000.6472. PMID 11401424.
Adra CN, Lelias JM, Kobayashi H, et al. (1994). "Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions.". Proc. Natl. Acad. Sci. U.S.A. 91 (21): 10178-82. PMID 7524084.