MS4A2

From Wikipedia, the free encyclopedia

Membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)

Identifiers

Symbol(s)

MS4A2; MS4A1; APY; ATOPY; FCER1B; FCERI; IGEL; IGER; IGHER

External IDs

OMIM: 147138 MGI: 95495 HomoloGene: 112

Gene ontology
Molecular Function:	• receptor activity • calcium channel activity • IgE binding
Cellular Component:	• integral to plasma membrane • external side of plasma membrane • membrane
Biological Process:	• humoral immune response • G-protein coupled receptor protein signaling pathway • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000139 (mRNA)
NP_000130 (protein)

NM_013516 (mRNA)
NP_038544 (protein)

Location

Chr 11: 59.61 - 59.62 Mb

Chr 19: 11.68 - 11.69 Mb

Pubmed search

[1]

[2]

Membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide), also known as MS4A2, is a human gene.^[1]

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members.^[1]

[edit] See also

FcεRI

[edit] References

^ ^a ^b Entrez Gene: MS4A2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide).

[edit] Further reading

Jouvin MH, Numerof RP, Kinet JP (1995). "Signal transduction through the conserved motifs of the high affinity IgE receptor Fc epsilon RI.". Semin. Immunol. 7 (1): 29-35. PMID 7612892.
Wilson BS, Pfeiffer JR, Oliver JM (2003). "FcepsilonRI signaling observed from the inside of the mast cell membrane.". Mol. Immunol. 38 (16-18): 1259-68. PMID 12217393.
Kraft S, Rana S, Jouvin MH, Kinet JP (2004). "The role of the FcepsilonRI beta-chain in allergic diseases.". Int. Arch. Allergy Immunol. 135 (1): 62-72. doi:10.1159/000080231. PMID 15316148.
Maekawa K, Imagawa N, Tanaka Y, Harada S (1992). "Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor.". FEBS Lett. 302 (2): 161-5. PMID 1386024.
Bieber T, de la Salle H, Wollenberg A, et al. (1992). "Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI).". J. Exp. Med. 175 (5): 1285-90. PMID 1533242.
Küster H, Zhang L, Brini AT, et al. (1992). "The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor.". J. Biol. Chem. 267 (18): 12782-7. PMID 1535625.
Le Coniat M, Kinet JP, Berger R (1990). "The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulin E are located on human chromosome band 1q23.". Immunogenetics 32 (3): 183-6. PMID 2146219.
Tedder TF, Streuli M, Schlossman SF, Saito H (1988). "Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 85 (1): 208-12. PMID 2448768.
Paolini R, Renard V, Vivier E, et al. (1995). "Different roles for the Fc epsilon RI gamma chain as a function of the receptor context.". J. Exp. Med. 181 (1): 247-55. PMID 7528770.
Shirakawa T, Li A, Dubowitz M, et al. (1994). "Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor.". Nat. Genet. 7 (2): 125-9. doi:10.1038/ng0694-125. PMID 7920628.
Kihara H, Siraganian RP (1994). "Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor.". J. Biol. Chem. 269 (35): 22427-32. PMID 8071371.
Sandford AJ, Shirakawa T, Moffatt MF, et al. (1993). "Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q.". Lancet 341 (8841): 332-4. PMID 8094113.
Szepetowski P, Gaudray P (1994). "FCER1B, a candidate gene for atopy, is located in 11q13 between CD20 and TCN1.". Genomics 19 (2): 399-400. PMID 8188278.
Daniels SE, Bhattacharrya S, James A, et al. (1996). "A genome-wide search for quantitative trait loci underlying asthma.". Nature 383 (6597): 247-50. doi:10.1038/383247a0. PMID 8805698.
Hill MR, Cookson WO (1997). "A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness.". Hum. Mol. Genet. 5 (7): 959-62. PMID 8817330.
Shirakawa T, Mao XQ, Sasaki S, et al. (1997). "Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population.". Hum. Mol. Genet. 5 (8): 1129-30. PMID 8842731.
Shirakawa T, Mao XQ, Sasaki S, et al. (1997). "Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population.". Hum. Mol. Genet. 5 (12): 2068. PMID 8968765.
Hendricks-Taylor LR, Motto DG, Zhang J, et al. (1997). "SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells.". J. Biol. Chem. 272 (2): 1363-7. PMID 8995445.
Kanzaki M, Lindorfer MA, Garrison JC, Kojima I (1997). "Activation of the calcium-permeable cation channel CD20 by alpha subunits of the Gi protein.". J. Biol. Chem. 272 (23): 14733-9. PMID 9169438.