MRPS33

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Mitochondrial ribosomal protein S33
Identifiers
Symbol(s) MRPS33; CGI-139; FLJ21123; MRP-S33; PTD003
External IDs MGI: 1338046 HomoloGene: 7729
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 51650 14548
Ensembl ENSG00000090263 ENSMUSG00000029918
Uniprot Q9Y291 Q58DZ5
Refseq NM_016071 (mRNA)
NP_057155 (protein)		 NM_001010930 (mRNA)
NP_001010930 (protein)
Location Chr 7: 140.35 - 140.36 Mb Chr 6: 39.73 - 39.74 Mb
Pubmed search [1] [2]

Mitochondrial ribosomal protein S33, also known as MRPS33, is a human gene.[1]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that is one of the more highly conserved mitochondrial ribosomal proteins among mammals, Drosophila and C. elegans. Splice variants that differ in the 5' UTR have been found for this gene; all variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q, 4p, 4q, and 20q[1]

[edit] References

  1. ^ a b Entrez Gene: MRPS33 mitochondrial ribosomal protein S33.

[edit] Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948. 
  • Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.". Genomics 81 (5): 468-80. PMID 12706105. 
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767-72. doi:10.1126/science.1083423. PMID 12690205. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Cavdar Koc E, Burkhart W, Blackburn K, et al. (2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present.". J. Biol. Chem. 276 (22): 19363-74. doi:10.1074/jbc.M100727200. PMID 11279123. 
  • Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703-13. PMID 10810093. 
  • "Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097-108. PMID 9847074. 
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