MRPL39

From Wikipedia, the free encyclopedia

Mitochondrial ribosomal protein L39

Identifiers

MRPL39; C21orf92; FLJ20451; L39mt; MGC104174; MGC3400; MRP-L5; MSTP003; PRED22; PRED66; RPML5

External IDs

Gene ontology
Molecular Function:	• molecular_function
Cellular Component:	• mitochondrion • mitochondrial ribosome • ribonucleoprotein complex
Biological Process:	• biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_017446 (mRNA)
NP_059142 (protein)

NM_017404 (mRNA)
NP_059100 (protein)

Location

Chr 21: 25.88 - 25.9 Mb

Chr 16: 84.6 - 84.62 Mb

Pubmed search

[1]

[2]

Mitochondrial ribosomal protein L39, also known as MRPL39, is a human gene.^[1]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q.^[1]

[edit] References

^ ^a ^b Entrez Gene: MRPL39 mitochondrial ribosomal protein L39.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
O'Brien TW, Fiesler SE, Denslow ND, et al. (2000). "Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences.". J. Biol. Chem. 274 (51): 36043–51. PMID 10593885.
Spirina O, Bykhovskaya Y, Kajava AV, et al. (2001). "Heart-specific splice-variant of a human mitochondrial ribosomal protein (mRNA processing; tissue specific splicing).". Gene 261 (2): 229–34. PMID 11167009.
Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.". Genomics 77 (1-2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
O'Brien TW (2002). "Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease.". Gene 286 (1): 73–9. PMID 11943462.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.". Genomics 81 (5): 468–80. PMID 12706105.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.