MRPL22

From Wikipedia, the free encyclopedia


Mitochondrial ribosomal protein L22
PDB rendering based on 2ftc.
Available structures: 2ftc
Identifiers
Symbol(s) MRPL22; DKFZp781F1071; HSPC158; MRP-L25; RPML25
External IDs MGI: 1333794 HomoloGene: 56664
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 29093 216767
Ensembl ENSG00000082515 ENSMUSG00000020514
Uniprot Q9NWU5 Q8BU88
Refseq NM_001014990 (mRNA)
NP_001014990 (protein)		 NM_175001 (mRNA)
NP_778166 (protein)
Location Chr 5: 154.3 - 154.33 Mb Chr 11: 57.99 - 58 Mb
Pubmed search [1] [2]

Mitochondrial ribosomal protein L22, also known as MRPL22, is a human gene.[1]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: MRPL22 mitochondrial ribosomal protein L22.

[edit] Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548. 
  • Goldschmidt-Reisin S, Kitakawa M, Herfurth E, et al. (1999). "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences.". J. Biol. Chem. 273 (52): 34828-36. PMID 9857009. 
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546-60. PMID 11042152. 
  • Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.". Genomics 77 (1-2): 65-70. doi:10.1006/geno.2001.6622. PMID 11543634. 
  • Koc EC, Burkhart W, Blackburn K, et al. (2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.". J. Biol. Chem. 276 (47): 43958-69. doi:10.1074/jbc.M106510200. PMID 11551941. 
  • O'Brien TW (2002). "Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease.". Gene 286 (1): 73-9. PMID 11943462. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.". Genomics 81 (5): 468-80. PMID 12706105. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
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