MRPL19

From Wikipedia, the free encyclopedia

Mitochondrial ribosomal protein L19

PDB rendering based on 2ftc.

Available structures: 2ftc

Identifiers

Symbol(s)

MRPL19; KIAA0104; MGC20675; MRP-L15; RLX1; RPML15

External IDs

MGI: 1926274 HomoloGene: 8851

Gene ontology
Molecular Function:	• structural constituent of ribosome
Cellular Component:	• intracellular • nucleus • mitochondrion • ribosome • nuclear membrane
Biological Process:	• translation

Orthologs

Human

Mouse

Refseq

NM_014763 (mRNA)
NP_055578 (protein)

NM_026490 (mRNA)
NP_080766 (protein)

Location

Chr 2: 75.73 - 75.75 Mb

Chr 6: 81.92 - 81.93 Mb

Pubmed search

[1]

[2]

Mitochondrial ribosomal protein L19, also known as MRPL19, is a human gene.^[1]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.^[1]

[edit] References

^ ^a ^b Entrez Gene: MRPL19 mitochondrial ribosomal protein L19.

[edit] Further reading

Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (1): 37–43. PMID 7788527.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074.
Graack HR, Bryant ML, O'Brien TW (2000). "Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle.". Biochemistry 38 (50): 16569–77. PMID 10600119.
Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins.". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria.". J. Biol. Chem. 276 (24): 21724–36. doi:10.1074/jbc.M100432200. PMID 11279069.
Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.". Genomics 77 (1-2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.". Genomics 81 (5): 468–80. PMID 12706105.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Anthoni H, Zucchelli M, Matsson H, et al. (2007). "A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia.". Hum. Mol. Genet. 16 (6): 667–77. doi:10.1093/hmg/ddm009. PMID 17309879.